H2AFZ
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| H2A histone family member Z | MIM:142763 | Ensembl:ENSG00000164032 | HGNC:HGNC:4741 | PA29119 | 4q23 |
GO terms in H2AFZ
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0031490 | chromatin DNA binding |
| MF | IDA | GO:0031492 | nucleosomal DNA binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | IEA | GO:0000786 | nucleosome |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0001740 | Barr body |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005719 | nuclear euchromatin |
| CC | IDA | GO:0005720 | nuclear heterochromatin |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0006325 | chromatin organization |
| BP | IBA | GO:0006342 | chromatin silencing |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0071392 | cellular response to estradiol stimulus |
Gene expression in normal tissue: H2AFZ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in H2AFZ
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1221632 | Meiotic synapsis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-171306 | Packaging Of Telomere Ends |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212300 | PRC2 methylates histones and DNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2299718 | Condensation of Prophase Chromosomes |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-427359 | SIRT1 negatively regulates rRNA expression |
| reactome | R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250924 | B-WICH complex positively regulates rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5334118 | DNA methylation |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| reactome | R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73728 | RNA Polymerase I Promoter Opening |
| reactome | R-HSA-73777 | RNA Polymerase I Chain Elongation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-774815 | Nucleosome assembly |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| reactome | R-HSA-912446 | Meiotic recombination |
| reactome | R-HSA-977225 | Amyloid fiber formation |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| pid | cmyb_pathway | C-MYB transcription factor network |
| wikipathways | WP183 | Proteasome Degradation |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in H2AFZ
CLASSFICATION
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