H2AFZ


Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:142763
PHARMGKB IDPA29119
Map Location4q23

GO terms in H2AFZ


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IDA GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
MF IDA GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
MF IBA GO:0003677 DNA binding
MF IPI GO:0005515 protein binding
MF IDA GO:0031490 chromatin DNA binding
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Gene expression in normal tissue: H2AFZ

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Metabolic pathways1

Pathways in H2AFZ


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1221632 Meiotic synapsis
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1474165 Reproduction
reactome R-HSA-1500620 Meiosis
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-157579 Telomere Maintenance
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in H2AFZ

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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