H2AFZ
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:142763 Ensembl IDEnsembl:ENSG00000164032 HGNC IDHGNC:HGNC:4741 PHARMGKB IDPA29119 Map Location4q23 |
GO terms in H2AFZ
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | IDA | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
MF | IBA | GO:0003677 | DNA binding |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0031490 | chromatin DNA binding |
Gene expression in normal tissue: H2AFZ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in H2AFZ
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1221632 | Meiotic synapsis |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1474165 | Reproduction |
reactome | R-HSA-1500620 | Meiosis |
reactome | R-HSA-157118 | Signaling by NOTCH |
reactome | R-HSA-157579 | Telomere Maintenance |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD68 | Paclitaxel | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in H2AFZ
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |