HAL
Summary: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609457 Ensembl IDEnsembl:ENSG00000084110 HGNC IDHGNC:HGNC:4806 PHARMGKB IDPA29181 Map Location12q23.1 | |||||
GO terms in HAL
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004397 | histidine ammonia-lyase activity |
| MF | IBA | GO:0004397 | histidine ammonia-lyase activity |
| MF | IBA | GO:0016841 | ammonia-lyase activity |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0006548 | histidine catabolic process |
| BP | TAS | GO:0006548 | histidine catabolic process |
Gene expression in normal tissue: HAL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HAL
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HAL
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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