HDAC1
Summary: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histone deacetylase 1 | MIM:601241 | Ensembl:ENSG00000116478 | HGNC:HGNC:4852 | PA29226 | 1p35.2-p35.1 |
GO terms in HDAC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | HDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | HDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IDA | GO:0001046 | core promoter sequence-specific DNA binding |
| MF | IPI | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IPI | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | IPI | GO:0002039 | p53 binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0004407 | histone deacetylase activity |
| MF | IMP | GO:0004407 | histone deacetylase activity |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | TAS | GO:0008134 | transcription factor binding |
| MF | ISS | GO:0019213 | deacetylase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | HDA | GO:0031492 | nucleosomal DNA binding |
| MF | IEA | GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) |
| MF | IDA | GO:0033558 | protein deacetylase activity |
| MF | IMP | GO:0033558 | protein deacetylase activity |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0047485 | protein N-terminus binding |
| MF | IPI | GO:0051059 | NF-kappaB binding |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006325 | chromatin organization |
| BP | IC | GO:0006338 | chromatin remodeling |
| BP | IGI | GO:0006346 | methylation-dependent chromatin silencing |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006476 | protein deacetylation |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0009913 | epidermal cell differentiation |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0010832 | negative regulation of myotube differentiation |
| BP | IMP | GO:0010870 | positive regulation of receptor biosynthetic process |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0016575 | histone deacetylation |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | ISS | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | ISS | GO:0042733 | embryonic digit morphogenesis |
| BP | HDA | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | ISS | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043922 | negative regulation by host of viral transcription |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| BP | ISS | GO:0060789 | hair follicle placode formation |
| BP | ISS | GO:0061029 | eyelid development in camera-type eye |
| BP | ISS | GO:0061198 | fungiform papilla formation |
| BP | IDA | GO:0070932 | histone H3 deacetylation |
| BP | IDA | GO:0070933 | histone H4 deacetylation |
| BP | IGI | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| CC | TAS | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0000785 | chromatin |
| CC | HDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016580 | Sin3 complex |
| CC | IDA | GO:0016581 | NuRD complex |
| CC | HDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: HDAC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDAC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3871 | Valproic acid pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pharmgkb | PA165959313 | Valproic Acid Pathway, Pharmacodynamics |
| pharmgkb | PA165964473 | Pathway_PA165964473 |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | e2f_pathway | E2F transcription factor network |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | notch_pathway | Notch signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | ranbp2pathway | Sumoylation by RanBP2 regulates transcriptional repression |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | telomerasepathway | Regulation of Telomerase |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Notch | Notch |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TWEAK | TWEAK |
| biocarta | g1pathway | cell cycle: g1/s check point |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | mta3pathway | downregulated of mta-3 in er-negative breast tumors |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | prc2pathway | the prc2 complex sets long-term gene silencing through modification of histone tails |
| biocarta | ranbp2pathway | sumoylation by ranbp2 regulates transcriptional repression |
| biocarta | tertpathway | overview of telomerase protein component gene htert transcriptional regulation |
| biocarta | wntpathway | wnt signaling pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6804758 | Regulation of TP53 Activity through Acetylation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD2 | PK-11195 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD229 | B02 | 1 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD494 | Neopeltolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDAC1
CLASSFICATION
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