HDAC2
Summary: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histone deacetylase 2 | MIM:605164 | Ensembl:ENSG00000196591 | HGNC:HGNC:4853 | PA29227 | 6q21 |
GO terms in HDAC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001975 | response to amphetamine |
| BP | IEA | GO:0003300 | cardiac muscle hypertrophy |
| BP | IC | GO:0006338 | chromatin remodeling |
| BP | IMP | GO:0006344 | maintenance of chromatin silencing |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0009913 | epidermal cell differentiation |
| BP | IEA | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IMP | GO:0010870 | positive regulation of receptor biosynthetic process |
| BP | ISS | GO:0010977 | negative regulation of neuron projection development |
| BP | ISS | GO:0016358 | dendrite development |
| BP | IMP | GO:0016575 | histone deacetylation |
| BP | IEA | GO:0031000 | response to caffeine |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0032732 | positive regulation of interleukin-1 production |
| BP | IEA | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | IC | GO:0032967 | positive regulation of collagen biosynthetic process |
| BP | IEA | GO:0034605 | cellular response to heat |
| BP | IEA | GO:0035094 | response to nicotine |
| BP | IEA | GO:0042220 | response to cocaine |
| BP | ISS | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IEA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | ISS | GO:0042733 | embryonic digit morphogenesis |
| BP | HDA | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | ISS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043392 | negative regulation of DNA binding |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IC | GO:0045347 | negative regulation of MHC class II biosynthetic process |
| BP | IMP | GO:0045862 | positive regulation of proteolysis |
| BP | IC | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IC | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048149 | behavioral response to ethanol |
| BP | IEA | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| BP | IEA | GO:0055093 | response to hyperoxia |
| BP | ISS | GO:0060789 | hair follicle placode formation |
| BP | IEA | GO:0061000 | negative regulation of dendritic spine development |
| BP | ISS | GO:0061029 | eyelid development in camera-type eye |
| BP | ISS | GO:0061198 | fungiform papilla formation |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | ISS | GO:0070932 | histone H3 deacetylation |
| BP | ISS | GO:0070933 | histone H4 deacetylation |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IEA | GO:1903351 | cellular response to dopamine |
| BP | IEA | GO:2000757 | negative regulation of peptidyl-lysine acetylation |
| CC | HDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016580 | Sin3 complex |
| CC | IDA | GO:0016581 | NuRD complex |
| CC | HDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0035098 | ESC/E(Z) complex |
| MF | HDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | HDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IPI | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004407 | histone deacetylase activity |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | ISS | GO:0019213 | deacetylase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0031072 | heat shock protein binding |
| MF | HDA | GO:0031492 | nucleosomal DNA binding |
| MF | IEA | GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) |
| MF | IMP | GO:0033558 | protein deacetylase activity |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IPI | GO:0051059 | NF-kappaB binding |
| MF | IEA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: HDAC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDAC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | telomerasepathway | Regulation of Telomerase |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| netpath | Pathway_Notch | Notch |
| netpath | Pathway_TNFalpha | TNFalpha |
| biocarta | etspathway | mets affect on macrophage differentiation |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | prc2pathway | the prc2 complex sets long-term gene silencing through modification of histone tails |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6804758 | Regulation of TP53 Activity through Acetylation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD945 | ML214 | 8 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD123 | Isoevodiamine | 8 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD971 | PARP inhibitor | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD193 | Fqi1 | 8 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD138 | PX 12 | 8 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 9 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 11 |
| iGMDRD100 | Zebularine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDAC2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.