ANXA4


Summary: Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:106491
PHARMGKB IDPA24832
Map Location2p13.3

GO terms in ANXA4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF NAS GO:0004859 phospholipase inhibitor activity
MF IDA GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF IDA GO:0005544 calcium-dependent phospholipid binding
MF NAS GO:0005544 calcium-dependent phospholipid binding
MF IPI GO:0042802 identical protein binding
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Gene expression in normal tissue: ANXA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in ANXA4


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Database
Pathway ID
Pathway Des.
netpath Pathway_EGFR1 EGFR1
wikipathways WP98 Prostaglandin Synthesis and Regulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANXA4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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