Summary: Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016].

annexin A4MIM:106491Ensembl:ENSG00000196975HGNC:HGNC:542PA248322p13.3

GO terms in ANXA4

Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0004859phospholipase inhibitor activity
MFIDAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIDAGO:0005544calcium-dependent phospholipid binding
MFNASGO:0005544calcium-dependent phospholipid binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0048306calcium-dependent protein binding
MFIPIGO:0051059NF-kappaB binding
CCIDAGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCIDAGO:0012506vesicle membrane
CCIDAGO:0031965nuclear membrane
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
BPIDAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0007165signal transduction
BPIEAGO:0007219Notch signaling pathway
BPIEPGO:0030855epithelial cell differentiation
BPIDAGO:0032088negative regulation of NF-kappaB transcription factor activity
BPTASGO:0043066negative regulation of apoptotic process
BPIEAGO:0043086negative regulation of catalytic activity
BPIMPGO:2000483negative regulation of interleukin-8 secretion

Gene expression in normal tissue: ANXA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ANXA4

DatabasePathway IDPathway Des.
wikipathwaysWP98Prostaglandin Synthesis and Regulation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANXA4