Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].

nuclear receptor subfamily 4 group A member 1MIM:139139Ensembl:ENSG00000123358HGNC:HGNC:7980PA3176112q13.13

GO terms in NR4A1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFISSGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFISSGO:0003677DNA binding
MFIEAGO:0003707steroid hormone receptor activity
MFIEAGO:0004879nuclear receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0035259glucocorticoid receptor binding
MFIBAGO:0043565sequence-specific DNA binding
MFIEAGO:0043565sequence-specific DNA binding
MFISSGO:0046982protein heterodimerization activity
BPIMPGO:0001938positive regulation of endothelial cell proliferation
BPIDAGO:0002042cell migration involved in sprouting angiogenesis
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0007165signal transduction
BPIEAGO:0030522intracellular receptor signaling pathway
BPIMPGO:0035767endothelial cell chemotaxis
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIMPGO:0044344cellular response to fibroblast growth factor stimulus
BPISSGO:0045444fat cell differentiation
BPISSGO:0045786negative regulation of cell cycle
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0061469regulation of type B pancreatic cell proliferation
BPIBAGO:0071376cellular response to corticotropin-releasing hormone stimulus
BPISSGO:0071376cellular response to corticotropin-releasing hormone stimulus
CCIBAGO:0005667transcription factor complex
CCIDAGO:0031965nuclear membrane

Gene expression in normal tissue: NR4A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NR4A1

DatabasePathway IDPathway Des.
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3987HDAC6 interactions
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-198693AKT phosphorylates targets in the nucleus
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR4A1