NR4A1
Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor subfamily 4 group A member 1 | MIM:139139 | Ensembl:ENSG00000123358 | HGNC:HGNC:7980 | PA31761 | 12q13.13 |
GO terms in NR4A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | IEA | GO:0004879 | nuclear receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0035259 | glucocorticoid receptor binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| MF | ISS | GO:0046982 | protein heterodimerization activity |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IDA | GO:0002042 | cell migration involved in sprouting angiogenesis |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0030522 | intracellular receptor signaling pathway |
| BP | IMP | GO:0035767 | endothelial cell chemotaxis |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IMP | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | ISS | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0061469 | regulation of type B pancreatic cell proliferation |
| BP | IBA | GO:0071376 | cellular response to corticotropin-releasing hormone stimulus |
| BP | ISS | GO:0071376 | cellular response to corticotropin-releasing hormone stimulus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0031965 | nuclear membrane |
Gene expression in normal tissue: NR4A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NR4A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3987 | HDAC6 interactions |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-198693 | AKT phosphorylates targets in the nucleus |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NR4A1
CLASSFICATION
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