TLX2
Summary: This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604240 Ensembl IDEnsembl:ENSG00000115297 HGNC IDHGNC:HGNC:5057 PHARMGKB IDPA35096 Map Location2p13.1 | |||||
GO terms in TLX2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001707 | mesoderm formation |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048484 | enteric nervous system development |
| BP | IEA | GO:0050774 | negative regulation of dendrite morphogenesis |
| CC | ND | GO:0005575 | cellular_component |
Gene expression in normal tissue: TLX2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLX2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
| wikipathways | WP2064 | Neural Crest Differentiation |
| pid | alk1pathway | ALK1 signaling events |
| pid | alk2pathway | ALK2 signaling events |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLX2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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