TLX2
Summary: This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| T cell leukemia homeobox 2 | MIM:604240 | Ensembl:ENSG00000115297 | HGNC:HGNC:5057 | PA35096 | 2p13.1 |
GO terms in TLX2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001707 | mesoderm formation |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048484 | enteric nervous system development |
| BP | IEA | GO:0050774 | negative regulation of dendrite morphogenesis |
| CC | ND | GO:0005575 | cellular_component |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
Gene expression in normal tissue: TLX2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLX2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
| wikipathways | WP2064 | Neural Crest Differentiation |
| pid | alk1pathway | ALK1 signaling events |
| pid | alk2pathway | ALK2 signaling events |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLX2
CLASSFICATION
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