HRH2


Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
histamine receptor H2MIM:142703Ensembl:ENSG00000113749HGNC:HGNC:5183PA294575q35.2

GO terms in HRH2


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0030425dendrite
BPIEAGO:0001698gastrin-induced gastric acid secretion
BPIEAGO:0003382epithelial cell morphogenesis
BPTASGO:0006955immune response
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPTASGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPIBAGO:0007268chemical synaptic transmission
BPIEAGO:0007613memory
BPIEAGO:0008542visual learning
BPIEAGO:0045907positive regulation of vasoconstriction
BPIEAGO:0048167regulation of synaptic plasticity
BPIEAGO:0048565digestive tract development
BPIEAGO:0048732gland development
BPIEAGO:1901998toxin transport
MFIBAGO:0004930G-protein coupled receptor activity
MFIBAGO:0004969histamine receptor activity
MFIBAGO:0004993G-protein coupled serotonin receptor activity
MFIBAGO:0030594neurotransmitter receptor activity

Gene expression in normal tissue: HRH2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HRH2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375280Amine ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-390650Histamine receptors
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-500792GPCR ligand binding
wikipathwaysWP2597Secretion of Hydrochloric Acid in Parietal Cells
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP58Monoamine GPCRs
smpdbSMP00225Esomeprazole Action Pathway
smpdbSMP00226Omeprazole Action Pathway
smpdbSMP00227Lansoprazole Action Pathway
smpdbSMP00228Pantoprazole Action Pathway
smpdbSMP00229Rabeprazole Action Pathway
smpdbSMP00230Ranitidine Action Pathway
smpdbSMP00231Famotidine Action Pathway
smpdbSMP00232Cimetidine Action Pathway
smpdbSMP00233Nizatidine Action Pathway
smpdbSMP00246Pirenzepine Action Pathway
smpdbSMP00335Intracellular Signalling Through Histamine H2 Receptor and Histamine
smpdbSMP00589Gastric Acid Production
smpdbSMP00617Cimetidine Metabolism Pathway
smpdbSMP00734Roxatidine acetate Action Pathway
smpdbSMP00735Metiamide Action Pathway
smpdbSMP00736Betazole Action Pathway
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HRH2

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