HSD3B1

Summary: The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namehydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
OMIM IDMIM:109715
Ensembl IDEnsembl:ENSG00000203857
HGNC IDHGNC:HGNC:5217
PHARMGKB IDPA29486
Map Location1p12

Gene Categories:

DRUGGABLE GENOME

GO terms in HSD3B1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
MF ISS GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
MF TAS GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
MF ISS GO:0004769 steroid delta-isomerase activity
MF TAS GO:0004769 steroid delta-isomerase activity
MF IBA GO:0016491 oxidoreductase activity
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Gene expression in normal tissue: HSD3B1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Metabolic pathways1

Pathways in HSD3B1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-193048 Androgen biosynthesis
reactome R-HSA-193993 Mineralocorticoid biosynthesis
reactome R-HSA-194002 Glucocorticoid biosynthesis
reactome R-HSA-196071 Metabolism of steroid hormones
reactome R-HSA-556833 Metabolism of lipids
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSD3B1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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