APLP2
Summary: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| amyloid beta precursor like protein 2 | MIM:104776 | Ensembl:ENSG00000084234 | HGNC:HGNC:598 | PA24885 | 11q24.3 |
GO terms in APLP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | NAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0031092 | platelet alpha granule membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008201 | heparin binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046914 | transition metal ion binding |
Gene expression in normal tissue: APLP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APLP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APLP2
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