APOC1
Summary: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:107710 Ensembl IDEnsembl:ENSG00000130208 HGNC IDHGNC:HGNC:607 PHARMGKB IDPA51 Map Location19q13.32 | |||||
GO terms in APOC1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | IEA | GO:0006641 | triglyceride metabolic process |
| BP | IEA | GO:0008203 | cholesterol metabolic process |
| BP | TAS | GO:0010873 | positive regulation of cholesterol esterification |
| BP | IDA | GO:0010900 | negative regulation of phosphatidylcholine catabolic process |
| BP | IDA | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance |
Gene expression in normal tissue: APOC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOC1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| pharmgkb | PA2031 | Statin Pathway, Pharmacodynamics |
| wikipathways | WP430 | Statin Pathway |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-382551 | Transport of small molecules |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOC1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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