IDE


Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:146680
PHARMGKB IDPA29629
Map Location10q23.33

GO terms in IDE


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001540 amyloid-beta binding
MF IEA GO:0001618 virus receptor activity
MF IDA GO:0004222 metalloendopeptidase activity
MF IPI GO:0005102 signaling receptor binding
MF IPI GO:0005515 protein binding
MF IDA GO:0005524 ATP binding
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Gene expression in normal tissue: IDE

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IDE


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Database
Pathway ID
Pathway Des.
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-5688426 Deubiquitination
reactome R-HSA-5689880 Ub-specific processing proteases
reactome R-HSA-597592 Post-translational protein modification
reactome R-HSA-9033241 Peroxisomal protein import
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IDE

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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