IDE
Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:146680 Ensembl IDEnsembl:ENSG00000119912 HGNC IDHGNC:HGNC:5381 PHARMGKB IDPA29629 Map Location10q23.33 |
GO terms in IDE
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0001540 | amyloid-beta binding |
MF | IEA | GO:0001618 | virus receptor activity |
MF | IDA | GO:0004222 | metalloendopeptidase activity |
MF | IPI | GO:0005102 | signaling receptor binding |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: IDE
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IDE
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-5688426 | Deubiquitination |
reactome | R-HSA-5689880 | Ub-specific processing proteases |
reactome | R-HSA-597592 | Post-translational protein modification |
reactome | R-HSA-9033241 | Peroxisomal protein import |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in IDE
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |