IDE
Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin degrading enzyme | MIM:146680 | Ensembl:ENSG00000119912 | HGNC:HGNC:5381 | PA29629 | 10q23.33 |
GO terms in IDE
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001540 | amyloid-beta binding |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0004222 | metalloendopeptidase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016887 | ATPase activity |
| MF | IEA | GO:0031626 | beta-endorphin binding |
| MF | IPI | GO:0042277 | peptide binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0043559 | insulin binding |
| MF | IPI | GO:0043559 | insulin binding |
| MF | IPI | GO:0140036 | ubiquitin-dependent protein binding |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005777 | peroxisome |
| CC | IBA | GO:0005782 | peroxisomal matrix |
| CC | TAS | GO:0005782 | peroxisomal matrix |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0031597 | cytosolic proteasome complex |
| BP | IDA | GO:0006508 | proteolysis |
| BP | TAS | GO:0006625 | protein targeting to peroxisome |
| BP | NAS | GO:0008286 | insulin receptor signaling pathway |
| BP | IDA | GO:0008340 | determination of adult lifespan |
| BP | IDA | GO:0010815 | bradykinin catabolic process |
| BP | IDA | GO:0010992 | ubiquitin recycling |
| BP | IDA | GO:0032461 | positive regulation of protein oligomerization |
| BP | IBA | GO:0042447 | hormone catabolic process |
| BP | IEA | GO:0042447 | hormone catabolic process |
| BP | IBA | GO:0043171 | peptide catabolic process |
| BP | TAS | GO:0045732 | positive regulation of protein catabolic process |
| BP | IEA | GO:0045861 | negative regulation of proteolysis |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IBA | GO:0050435 | amyloid-beta metabolic process |
| BP | IDA | GO:0050435 | amyloid-beta metabolic process |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IEA | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IBA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | IDA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | ISS | GO:0097242 | amyloid-beta clearance |
| BP | IDA | GO:1901142 | insulin metabolic process |
| BP | IDA | GO:1901143 | insulin catabolic process |
Gene expression in normal tissue: IDE
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IDE
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-9033241 | Peroxisomal protein import |
| reactome | R-HSA-9033241 | Peroxisomal protein import |
| wikipathways | WP2059 | Alzheimers Disease |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IDE
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