TUBB2B
Summary: The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612850 Ensembl IDEnsembl:ENSG00000137285 HGNC IDHGNC:HGNC:30829 PHARMGKB IDPA142670671 Map Location6p25.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in TUBB2B
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005874 | microtubule |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
Gene expression in normal tissue: TUBB2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TUBB2B
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| reactome | R-HSA-109582 | Hemostasis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TUBB2B
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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