TUBB2B
Summary: The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tubulin beta 2B class IIb | MIM:612850 | Ensembl:ENSG00000137285 | HGNC:HGNC:30829 | PA142670671 | 6p25.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TUBB2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005874 | microtubule |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IBA | GO:0001764 | neuron migration |
| BP | IMP | GO:0001764 | neuron migration |
| BP | IEA | GO:0007010 | cytoskeleton organization |
| BP | IBA | GO:0007017 | microtubule-based process |
| BP | IMP | GO:0007017 | microtubule-based process |
| BP | IMP | GO:1902669 | positive regulation of axon guidance |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IBA | GO:0005200 | structural constituent of cytoskeleton |
| MF | IEA | GO:0005200 | structural constituent of cytoskeleton |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005525 | GTP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: TUBB2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TUBB2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-157858 | Gap junction trafficking and regulation |
| reactome | R-HSA-157858 | Gap junction trafficking and regulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-190828 | Gap junction trafficking |
| reactome | R-HSA-190828 | Gap junction trafficking |
| reactome | R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| reactome | R-HSA-190861 | Gap junction assembly |
| reactome | R-HSA-190861 | Gap junction assembly |
| reactome | R-HSA-190872 | Transport of connexons to the plasma membrane |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC |
| reactome | R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| reactome | R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC |
| reactome | R-HSA-389977 | Post-chaperonin tubulin folding pathway |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620924 | Intraflagellar transport |
| reactome | R-HSA-5626467 | RHO GTPases activate IQGAPs |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin |
| reactome | R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| reactome | R-HSA-983189 | Kinesins |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TUBB2B
CLASSFICATION
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