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IGF2

Summary: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
insulin like growth factor 2	MIM:147470	Ensembl:ENSG00000167244	HGNC:HGNC:5466	PA29699	11p15.5

Gene Categories:

GROWTH FACTOR DRUGGABLE GENOME HISTONE MODIFICATION SERINE THREONINE KINASE HORMONE ACTIVITY CLINICALLY ACTIONABLE KINASE TUMOR SUPPRESSOR

GO terms in IGF2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	ISS	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	TAS	GO:0001501	skeletal system development
BP	IEA	GO:0001649	osteoblast differentiation
BP	ISS	GO:0001701	in utero embryonic development
BP	ISS	GO:0001892	embryonic placenta development
BP	ISS	GO:0001934	positive regulation of protein phosphorylation
BP	TAS	GO:0002576	platelet degranulation
BP	IEA	GO:0006006	glucose metabolic process
BP	TAS	GO:0006349	regulation of gene expression by genetic imprinting
BP	NAS	GO:0006355	regulation of transcription, DNA-templated
BP	TAS	GO:0007275	multicellular organism development
BP	IC	GO:0008284	positive regulation of cell proliferation
BP	IDA	GO:0008284	positive regulation of cell proliferation
BP	TAS	GO:0008286	insulin receptor signaling pathway
BP	IEA	GO:0009887	animal organ morphogenesis
BP	IEA	GO:0010469	regulation of signaling receptor activity
BP	IEA	GO:0031017	exocrine pancreas development
BP	ISS	GO:0031056	regulation of histone modification
BP	ISS	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
BP	IEA	GO:0040018	positive regulation of multicellular organism growth
BP	IDA	GO:0042104	positive regulation of activated T cell proliferation
BP	ISS	GO:0043085	positive regulation of catalytic activity
BP	IDA	GO:0043410	positive regulation of MAPK cascade
BP	TAS	GO:0044267	cellular protein metabolic process
BP	ISS	GO:0045725	positive regulation of glycogen biosynthetic process
BP	IDA	GO:0045840	positive regulation of mitotic nuclear division
BP	IEA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IDA	GO:0046628	positive regulation of insulin receptor signaling pathway
BP	ISS	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
BP	IEA	GO:0051146	striated muscle cell differentiation
BP	ISS	GO:0051147	regulation of muscle cell differentiation
BP	IEA	GO:0051781	positive regulation of cell division
BP	IDA	GO:0051897	positive regulation of protein kinase B signaling
BP	ISS	GO:0060669	embryonic placenta morphogenesis
BP	IEA	GO:0071902	positive regulation of protein serine/threonine kinase activity
BP	ISS	GO:2000467	positive regulation of glycogen (starch) synthase activity
CC	TAS	GO:0005576	extracellular region
CC	IEA	GO:0005615	extracellular space
CC	TAS	GO:0031093	platelet alpha granule lumen
MF	IPI	GO:0005158	insulin receptor binding
MF	IMP	GO:0005159	insulin-like growth factor receptor binding
MF	IDA	GO:0005178	integrin binding
MF	IEA	GO:0005179	hormone activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0008083	growth factor activity
MF	ISS	GO:0043539	protein serine/threonine kinase activator activity
MF	ISS	GO:0048018	receptor ligand activity

Gene expression in normal tissue: IGF2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGF2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114608	Platelet degranulation
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactome	R-HSA-2428924	IGF1R signaling cascade
reactome	R-HSA-2428928	IRS-related events triggered by IGF1R
reactome	R-HSA-2428933	SHC-related events triggered by IGF1R
reactome	R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-76005	Response to elevated platelet cytosolic Ca2+
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
wikipathways	WP2406	Cardiac Progenitor Differentiation
wikipathways	WP254	Apoptosis
wikipathways	WP2593	JAK-STAT
wikipathways	WP3584	MECP2 and Associated Rett Syndrome
wikipathways	WP3639	Apoptotic Signaling Pathway
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP474	Endochondral Ossification

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD462	OSI-906 (Linsitinib)	2
iGMDRD117	Docetaxel	1
iGMDRD816	anti-EGFR mAbs	1
iGMDRD898	EGFR mAb inhibitor	1
iGMDRD800	Cabazitaxel	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGF2

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