Summary: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

insulin like growth factor 2MIM:147470Ensembl:ENSG00000167244HGNC:HGNC:5466PA2969911p15.5

GO terms in IGF2

Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0001501skeletal system development
BPIEAGO:0001649osteoblast differentiation
BPISSGO:0001701in utero embryonic development
BPISSGO:0001892embryonic placenta development
BPISSGO:0001934positive regulation of protein phosphorylation
BPTASGO:0002576platelet degranulation
BPIEAGO:0006006glucose metabolic process
BPTASGO:0006349regulation of gene expression by genetic imprinting
BPNASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0007275multicellular organism development
BPICGO:0008284positive regulation of cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPTASGO:0008286insulin receptor signaling pathway
BPIEAGO:0009887animal organ morphogenesis
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0031017exocrine pancreas development
BPISSGO:0031056regulation of histone modification
BPISSGO:0038028insulin receptor signaling pathway via phosphatidylinositol 3-kinase
BPIEAGO:0040018positive regulation of multicellular organism growth
BPIDAGO:0042104positive regulation of activated T cell proliferation
BPISSGO:0043085positive regulation of catalytic activity
BPIDAGO:0043410positive regulation of MAPK cascade
BPTASGO:0044267cellular protein metabolic process
BPISSGO:0045725positive regulation of glycogen biosynthetic process
BPIDAGO:0045840positive regulation of mitotic nuclear division
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046628positive regulation of insulin receptor signaling pathway
BPISSGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0051146striated muscle cell differentiation
BPISSGO:0051147regulation of muscle cell differentiation
BPIEAGO:0051781positive regulation of cell division
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0060669embryonic placenta morphogenesis
BPIEAGO:0071902positive regulation of protein serine/threonine kinase activity
BPISSGO:2000467positive regulation of glycogen (starch) synthase activity
CCTASGO:0005576extracellular region
CCIEAGO:0005615extracellular space
CCTASGO:0031093platelet alpha granule lumen
MFIPIGO:0005158insulin receptor binding
MFIMPGO:0005159insulin-like growth factor receptor binding
MFIDAGO:0005178integrin binding
MFIEAGO:0005179hormone activity
MFIPIGO:0005515protein binding
MFIDAGO:0008083growth factor activity
MFISSGO:0043539protein serine/threonine kinase activator activity
MFISSGO:0048018receptor ligand activity

Gene expression in normal tissue: IGF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGF2

DatabasePathway IDPathway Des.
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428933SHC-related events triggered by IGF1R
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP474Endochondral Ossification

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD462OSI-906 (Linsitinib)2
iGMDRD816anti-EGFR mAbs1
iGMDRD898EGFR mAb inhibitor1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGF2