SELENOV
Summary: This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| selenoprotein V | MIM:607919 | Ensembl:ENSG00000186838 | HGNC:HGNC:30399 | 19q13.2 |
GO terms in SELENOV
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0010269 | response to selenium ion |
| CC | IBA | GO:0005829 | cytosol |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SELENOV
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SELENOV
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP28 | Selenium Metabolism and Selenoproteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SELENOV
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