IL6R
Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:147880 Ensembl IDEnsembl:ENSG00000160712 HGNC IDHGNC:HGNC:6019 PHARMGKB IDPA29835 Map Location1q21.3 | |||||
GO terms in IL6R
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IMP | GO:0004897 | ciliary neurotrophic factor receptor activity |
| MF | IDA | GO:0004915 | interleukin-6 receptor activity |
| MF | IPI | GO:0005138 | interleukin-6 receptor binding |
| MF | IBA | GO:0005143 | interleukin-12 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: IL6R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL6R
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | il6pathway | il 6 signaling pathway |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-112411 | MAPK1 (ERK2) activation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL6R
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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