IL6R
Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 6 receptor | MIM:147880 | Ensembl:ENSG00000160712 | HGNC:HGNC:6019 | PA29835 | 1q21.3 |
GO terms in IL6R
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IMP | GO:0004897 | ciliary neurotrophic factor receptor activity |
| MF | IDA | GO:0004915 | interleukin-6 receptor activity |
| MF | IPI | GO:0005138 | interleukin-6 receptor binding |
| MF | IBA | GO:0005143 | interleukin-12 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IBA | GO:0019955 | cytokine binding |
| MF | IBA | GO:0019981 | interleukin-6 binding |
| MF | IPI | GO:0019981 | interleukin-6 binding |
| MF | IBA | GO:0042164 | interleukin-12 alpha subunit binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0045519 | interleukin-23 receptor binding |
| MF | IPI | GO:0070119 | ciliary neurotrophic factor binding |
| BP | TAS | GO:0002384 | hepatic immune response |
| BP | IC | GO:0002548 | monocyte chemotaxis |
| BP | TAS | GO:0002690 | positive regulation of leukocyte chemotaxis |
| BP | IBA | GO:0002827 | positive regulation of T-helper 1 type immune response |
| BP | TAS | GO:0006953 | acute-phase response |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0010536 | positive regulation of activation of Janus kinase activity |
| BP | IDA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IC | GO:0031018 | endocrine pancreas development |
| BP | IMP | GO:0031018 | endocrine pancreas development |
| BP | IDA | GO:0032722 | positive regulation of chemokine production |
| BP | IBA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IDA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IBA | GO:0032816 | positive regulation of natural killer cell activation |
| BP | IDA | GO:0034097 | response to cytokine |
| BP | IBA | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | IBA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IMP | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | TAS | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IDA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IBA | GO:0050671 | positive regulation of lymphocyte proliferation |
| BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IBA | GO:0051135 | positive regulation of NK T cell activation |
| BP | IBA | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | IMP | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | TAS | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | IMP | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway |
| BP | TAS | GO:0097191 | extrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005896 | interleukin-6 receptor complex |
| CC | IDA | GO:0005896 | interleukin-6 receptor complex |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IBA | GO:0043514 | interleukin-12 complex |
| CC | IDA | GO:0070110 | ciliary neurotrophic factor receptor complex |
| CC | IBA | GO:0070743 | interleukin-23 complex |
Gene expression in normal tissue: IL6R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL6R
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | il6pathway | il 6 signaling pathway |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-112411 | MAPK1 (ERK2) activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | shp2_pathway | SHP2 signaling |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| netpath | Pathway_IL6 | IL6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL6R
CLASSFICATION
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