CXCL8
Summary: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-X-C motif chemokine ligand 8 | MIM:146930 | Ensembl:ENSG00000169429 | HGNC:HGNC:6025 | PA29841 | 4q13.3 |
GO terms in CXCL8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005153 | interleukin-8 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008009 | chemokine activity |
| MF | IDA | GO:0008009 | chemokine activity |
| MF | TAS | GO:0008009 | chemokine activity |
| MF | IBA | GO:0045236 | CXCR chemokine receptor binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| BP | TAS | GO:0001525 | angiogenesis |
| BP | IDA | GO:0002237 | response to molecule of bacterial origin |
| BP | TAS | GO:0006935 | chemotaxis |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019722 | calcium-mediated signaling |
| BP | IDA | GO:0030155 | regulation of cell adhesion |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IDA | GO:0030593 | neutrophil chemotaxis |
| BP | IGI | GO:0030593 | neutrophil chemotaxis |
| BP | IBA | GO:0030595 | leukocyte chemotaxis |
| BP | IDA | GO:0031623 | receptor internalization |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0036499 | PERK-mediated unfolded protein response |
| BP | IDA | GO:0042119 | neutrophil activation |
| BP | TAS | GO:0042119 | neutrophil activation |
| BP | IEP | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | IDA | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| BP | IDA | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | IEP | GO:0048566 | embryonic digestive tract development |
| BP | IGI | GO:0050930 | induction of positive chemotaxis |
| BP | IBA | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| BP | IBA | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEP | GO:0071347 | cellular response to interleukin-1 |
| BP | IEP | GO:0071356 | cellular response to tumor necrosis factor |
| BP | TAS | GO:0090023 | positive regulation of neutrophil chemotaxis |
| BP | IMP | GO:2000535 | regulation of entry of bacterium into host cell |
Gene expression in normal tissue: CXCL8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CXCL8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2753 | ATF4 activates genes |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP3287 | Overview of nanoparticle effects |
| wikipathways | WP3391 | Senescence-Associated Secretory Phenotype (SASP) |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-380994 | ATF4 activates genes |
| reactome | R-HSA-381042 | PERK regulates gene expression |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CXCL8
CLASSFICATION
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