IL11RA
Summary: Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 11 receptor subunit alpha | MIM:600939 | Ensembl:ENSG00000137070 | HGNC:HGNC:5967 | PA29782 | 9p13.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL11RA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IEA | GO:0004896 | cytokine receptor activity |
| MF | IBA | GO:0004921 | interleukin-11 receptor activity |
| MF | IBA | GO:0019955 | cytokine binding |
| MF | IBA | GO:0019970 | interleukin-11 binding |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IMP | GO:0032502 | developmental process |
| BP | IMP | GO:0060322 | head development |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
Gene expression in normal tissue: IL11RA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL11RA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions |
| netpath | Pathway_IL11 | IL11 |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL11RA
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