IL13RA1
Summary: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300119 Ensembl IDEnsembl:ENSG00000131724 HGNC IDHGNC:HGNC:5974 PHARMGKB IDPA200 Map LocationXq24 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in IL13RA1
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IEA | GO:0004896 | cytokine receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016515 | interleukin-13 receptor activity |
| MF | IBA | GO:0019955 | cytokine binding |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: IL13RA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL13RA1
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| wikipathways | WP3945 | TYROBP Causal Network |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL13RA1
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.