IL13RA1
Summary: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 13 receptor subunit alpha 1 | MIM:300119 | Ensembl:ENSG00000131724 | HGNC:HGNC:5974 | PA200 | Xq24 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL13RA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IEA | GO:0004896 | cytokine receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016515 | interleukin-13 receptor activity |
| MF | IBA | GO:0019955 | cytokine binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005898 | interleukin-13 receptor complex |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
Gene expression in normal tissue: IL13RA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL13RA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| wikipathways | WP3945 | TYROBP Causal Network |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| pid | il4_2pathway | IL4-mediated signaling events |
| netpath | Pathway_IL4 | IL4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL13RA1
CLASSFICATION
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