IL16


Summary: The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:603035
PHARMGKB IDPA29793
Map Location15q25.1

Gene Categories:

DRUGGABLE GENOME

GO terms in IL16


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0005125 cytokine activity
MF IPI GO:0042609 CD4 receptor binding
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006355 regulation of transcription, DNA-templated
BP TAS GO:0006955 immune response
BP IEA GO:0010469 regulation of signaling receptor activity
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Gene expression in normal tissue: IL16

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL16


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-168256 Immune System
reactome R-HSA-449147 Signaling by Interleukins
reactome R-HSA-449836 Other interleukin signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL16

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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