IMPDH2
Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inosine monophosphate dehydrogenase 2 | MIM:146691 | Ensembl:ENSG00000178035 | HGNC:HGNC:6053 | PA29863 | 3p21.31 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IMPDH2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0005778 | peroxisomal membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | IEA | GO:0006177 | GMP biosynthetic process |
| BP | IBA | GO:0006183 | GTP biosynthetic process |
| BP | IDA | GO:0007623 | circadian rhythm |
| BP | TAS | GO:0009168 | purine ribonucleoside monophosphate biosynthetic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0046651 | lymphocyte proliferation |
| BP | IEA | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| BP | IEA | GO:0071353 | cellular response to interleukin-4 |
| MF | IDA | GO:0000166 | nucleotide binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003723 | RNA binding |
| MF | EXP | GO:0003938 | IMP dehydrogenase activity |
| MF | IBA | GO:0003938 | IMP dehydrogenase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: IMPDH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IMPDH2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis |
| reactome | R-HSA-8956320 | Nucleobase biosynthesis |
| smpdb | SMP00652 | Mycophenolic Acid Metabolism Pathway |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics |
| humancyc | PWY-5695 | urate biosynthesis/inosine 5,-phosphate degradation |
| humancyc | PWY-6353 | purine nucleotides degradation |
| humancyc | PWY-7221 | guanosine ribonucleotides de novo biosynthesis |
| humancyc | PWY-7228 | guanosine nucleotides de novo biosynthesis |
| humancyc | PWY-841 | purine nucleotides de novo biosynthesis |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IMPDH2
CLASSFICATION
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