IMPDH2


Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inosine monophosphate dehydrogenase 2MIM:146691Ensembl:ENSG00000178035HGNC:HGNC:6053PA298633p21.31

Gene Categories:

DRUGGABLE GENOME

GO terms in IMPDH2


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCHDAGO:0005778peroxisomal membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane
CCTASGO:0034774secretory granule lumen
CCHDAGO:0070062extracellular exosome
CCTASGO:1904813ficolin-1-rich granule lumen
BPIEAGO:0006177GMP biosynthetic process
BPIBAGO:0006183GTP biosynthetic process
BPIDAGO:0007623circadian rhythm
BPTASGO:0009168purine ribonucleoside monophosphate biosynthetic process
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0046651lymphocyte proliferation
BPIEAGO:0051289protein homotetramerization
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0060041retina development in camera-type eye
BPIEAGO:0071353cellular response to interleukin-4
MFIDAGO:0000166nucleotide binding
MFIEAGO:0003677DNA binding
MFIEAGO:0003723RNA binding
MFEXPGO:0003938IMP dehydrogenase activity
MFIBAGO:0003938IMP dehydrogenase activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: IMPDH2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IMPDH2


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-15869Metabolism of nucleotides
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-73817Purine ribonucleoside monophosphate biosynthesis
reactomeR-HSA-8956320Nucleobase biosynthesis
smpdbSMP00652Mycophenolic Acid Metabolism Pathway
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00983Drug metabolism - other enzymes - Homo sapiens (human)
pharmgkbPA165964832Mycophenolic acid Pathway, Pharmacokinetics
pharmgkbPA165964832Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics
humancycPWY-5695urate biosynthesis/inosine 5,-phosphate degradation
humancycPWY-6353purine nucleotides degradation
humancycPWY-7221guanosine ribonucleotides de novo biosynthesis
humancycPWY-7228guanosine nucleotides de novo biosynthesis
humancycPWY-841purine nucleotides de novo biosynthesis
humancycPWY66-409superpathway of purine nucleotide salvage

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IMPDH2

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