INPP4A


Summary: This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in INPP4A


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
BP TAS GO:0006661 phosphatidylinositol biosynthetic process
BP TAS GO:0007165 signal transduction
BP IEA GO:0016311 dephosphorylation
BP IEA GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
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Gene expression in normal tissue: INPP4A

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4

Gene-drug pathway distribution

Cell cycle2undefined1Chromatin histone methylation1

Pathways in INPP4A


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1483249 Inositol phosphate metabolism
reactome R-HSA-1483255 PI Metabolism
reactome R-HSA-1483257 Phospholipid metabolism
reactome R-HSA-1660499 Synthesis of PIPs at the plasma membrane
reactome R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD652 UNC0638 1
iGMDRD719 IOX2 1
iGMDRD432 AT-7519 1
iGMDRD1015 THZ-2-102-1 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INPP4A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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