INPP4A


Summary: This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inositol polyphosphate-4-phosphatase type I AMIM:600916Ensembl:ENSG00000040933HGNC:HGNC:6074PA298822q11.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in INPP4A


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
BPTASGO:0006661phosphatidylinositol biosynthetic process
BPTASGO:0007165signal transduction
BPIEAGO:0016311dephosphorylation
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0043647inositol phosphate metabolic process
MFIPIGO:0005515protein binding
MFIBAGO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
MFTASGO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
MFTASGO:0017161inositol-1,3,4-trisphosphate 4-phosphatase activity
MFIEAGO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
MFTASGO:0052828inositol-3,4-bisphosphate 4-phosphatase activity

Gene expression in normal tissue: INPP4A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INPP4A


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-1660516Synthesis of PIPs at the early endosome membrane
reactomeR-HSA-1855183Synthesis of IP2, IP, and Ins in the cytosol
reactomeR-HSA-556833Metabolism of lipids
humancycPWY-63683-phosphoinositide degradation
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
wikipathwaysWP481Insulin Signaling
smpdbSMP00011Inositol Metabolism
smpdbSMP00462Inositol Phosphate Metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD652UNC06381
iGMDRD719IOX21
iGMDRD432AT-75191
iGMDRD1015THZ-2-102-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INPP4A

​​​​