INPP5B


Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inositol polyphosphate-5-phosphatase BMIM:147264Ensembl:ENSG00000204084HGNC:HGNC:6077PA298851p34.3

Gene Categories:

DRUGGABLE GENOME

GO terms in INPP5B


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005793endoplasmic reticulum-Golgi intermediate compartment
CCIEAGO:0005794Golgi apparatus
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIBAGO:0016020membrane
CCIDAGO:0016020membrane
CCIBAGO:0016021integral component of membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0030670phagocytic vesicle membrane
CCIEAGO:0031901early endosome membrane
BPIBAGO:0001701in utero embryonic development
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0007165signal transduction
BPIBAGO:0007283spermatogenesis
BPIEAGO:0007283spermatogenesis
BPIBAGO:0030317flagellated sperm motility
BPIEAGO:0030317flagellated sperm motility
BPIEAGO:0043547positive regulation of GTPase activity
BPTASGO:0043647inositol phosphate metabolic process
BPIBAGO:0046855inositol phosphate dephosphorylation
BPIBAGO:0046856phosphatidylinositol dephosphorylation
BPIDAGO:0046856phosphatidylinositol dephosphorylation
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIBAGO:0070613regulation of protein processing
BPIEAGO:0070613regulation of protein processing
MFIBAGO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
MFIDAGO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
MFTASGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0052658inositol-1,4,5-trisphosphate 5-phosphatase activity
MFTASGO:0052658inositol-1,4,5-trisphosphate 5-phosphatase activity
MFTASGO:0052659inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
MFIBAGO:0052745inositol phosphate phosphatase activity

Gene expression in normal tissue: INPP5B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INPP5B


DatabasePathway IDPathway Des.
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
humancycPWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
humancycPWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
humancycPWY-6363D-myo-inositol (1,4,5)-trisphosphate degradation
humancycPWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
humancycPWY-63683-phosphoinositide degradation
humancycPWY-6371superpathway of inositol phosphate compounds
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1855183Synthesis of IP2, IP, and Ins in the cytosol
reactomeR-HSA-1855204Synthesis of IP3 and IP4 in the cytosol
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INPP5B

​​​​