INPP5B
Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inositol polyphosphate-5-phosphatase B | MIM:147264 | Ensembl:ENSG00000204084 | HGNC:HGNC:6077 | PA29885 | 1p34.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in INPP5B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030670 | phagocytic vesicle membrane |
| CC | IEA | GO:0031901 | early endosome membrane |
| BP | IBA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0030317 | flagellated sperm motility |
| BP | IEA | GO:0030317 | flagellated sperm motility |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IBA | GO:0046855 | inositol phosphate dephosphorylation |
| BP | IBA | GO:0046856 | phosphatidylinositol dephosphorylation |
| BP | IDA | GO:0046856 | phosphatidylinositol dephosphorylation |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IBA | GO:0070613 | regulation of protein processing |
| BP | IEA | GO:0070613 | regulation of protein processing |
| MF | IBA | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
| MF | IDA | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity |
| MF | TAS | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity |
| MF | TAS | GO:0052659 | inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity |
| MF | IBA | GO:0052745 | inositol phosphate phosphatase activity |
Gene expression in normal tissue: INPP5B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INPP5B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| humancyc | PWY-6358 | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism |
| humancyc | PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
| humancyc | PWY-6363 | D-myo-inositol (1,4,5)-trisphosphate degradation |
| humancyc | PWY-6364 | D-myo-inositol (1,3,4)-trisphosphate biosynthesis |
| humancyc | PWY-6368 | 3-phosphoinositide degradation |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol |
| reactome | R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INPP5B
CLASSFICATION
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