INPP5B
Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:147264 Ensembl IDEnsembl:ENSG00000204084 HGNC IDHGNC:HGNC:6077 PHARMGKB IDPA29885 Map Location1p34.3 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in INPP5B
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: INPP5B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INPP5B
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| humancyc | PWY-6358 | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism |
| humancyc | PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
| humancyc | PWY-6363 | D-myo-inositol (1,4,5)-trisphosphate degradation |
| humancyc | PWY-6364 | D-myo-inositol (1,3,4)-trisphosphate biosynthesis |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INPP5B
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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