INSM1
Summary: Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
INSM transcriptional repressor 1 | MIM:600010 | Ensembl:ENSG00000173404 | HGNC:HGNC:6090 | PA29897 | 20p11.23 |
Gene Categories:
TUMOR SUPPRESSORGO terms in INSM1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IDA | GO:0001933 | negative regulation of protein phosphorylation |
BP | ISS | GO:0003309 | type B pancreatic cell differentiation |
BP | ISS | GO:0003310 | pancreatic A cell differentiation |
BP | IEA | GO:0003323 | type B pancreatic cell development |
BP | ISS | GO:0003358 | noradrenergic neuron development |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IEA | GO:0007049 | cell cycle |
BP | IDA | GO:0008285 | negative regulation of cell proliferation |
BP | ISS | GO:0010468 | regulation of gene expression |
BP | IEA | GO:0030335 | positive regulation of cell migration |
BP | TAS | GO:0031018 | endocrine pancreas development |
BP | ISS | GO:0042421 | norepinephrine biosynthetic process |
BP | IDA | GO:0043254 | regulation of protein complex assembly |
BP | ISS | GO:0045597 | positive regulation of cell differentiation |
BP | IDA | GO:0060290 | transdifferentiation |
BP | ISS | GO:0061104 | adrenal chromaffin cell differentiation |
BP | ISS | GO:0061549 | sympathetic ganglion development |
BP | IDA | GO:0071158 | positive regulation of cell cycle arrest |
BP | ISS | GO:2000179 | positive regulation of neural precursor cell proliferation |
CC | ISS | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0017053 | transcriptional repressor complex |
MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
MF | IPI | GO:0030332 | cyclin binding |
MF | IDA | GO:0031490 | chromatin DNA binding |
MF | IPI | GO:0042826 | histone deacetylase binding |
MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: INSM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INSM1
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-186712 | Regulation of beta-cell development |
reactome | R-HSA-210746 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in INSM1