INSM1
Summary: Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600010 Ensembl IDEnsembl:ENSG00000173404 HGNC IDHGNC:HGNC:6090 PHARMGKB IDPA29897 Map Location20p11.23 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in INSM1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | ISS | GO:0003309 | type B pancreatic cell differentiation |
| BP | ISS | GO:0003310 | pancreatic A cell differentiation |
| BP | IEA | GO:0003323 | type B pancreatic cell development |
| BP | ISS | GO:0003358 | noradrenergic neuron development |
Gene expression in normal tissue: INSM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INSM1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-210746 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INSM1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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