EIF3E
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 3 subunit E | MIM:602210 | Ensembl:ENSG00000104408 | HGNC:HGNC:3277 | PA27705 | 8q23.1 |
GO terms in EIF3E
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | IBA | GO:0006413 | translational initiation |
| BP | IC | GO:0006413 | translational initiation |
| BP | IDA | GO:0006413 | translational initiation |
| BP | TAS | GO:0006413 | translational initiation |
| BP | NAS | GO:0006446 | regulation of translational initiation |
| BP | IPI | GO:0045727 | positive regulation of translation |
| BP | NAS | GO:0045947 | negative regulation of translational initiation |
| BP | IPI | GO:1902416 | positive regulation of mRNA binding |
| CC | NAS | GO:0000785 | chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | IDA | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | NAS | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0016605 | PML body |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003743 | translation initiation factor activity |
| MF | IC | GO:0003743 | translation initiation factor activity |
| MF | IC | GO:0003743 | translation initiation factor activity |
| MF | IDA | GO:0003743 | translation initiation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
Gene expression in normal tissue: EIF3E
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF3E
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| wikipathways | WP107 | Translation Factors |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF3E
CLASSFICATION
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