Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

integrin subunit alpha 6MIM:147556Ensembl:ENSG00000091409HGNC:HGNC:6142PA299422q31.1

GO terms in ITGA6

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFIDAGO:0031994insulin-like growth factor I binding
MFIDAGO:0038132neuregulin binding
MFIEAGO:0043236laminin binding
MFHDAGO:0045296cadherin binding
MFIEAGO:0046872metal ion binding
BPTASGO:0007044cell-substrate junction assembly
BPIEAGO:0007160cell-matrix adhesion
BPIEAGO:0007229integrin-mediated signaling pathway
BPIEPGO:0010668ectodermal cell differentiation
BPIEAGO:0010811positive regulation of cell-substrate adhesion
BPIEAGO:0022409positive regulation of cell-cell adhesion
BPTASGO:0030198extracellular matrix organization
BPIMPGO:0030335positive regulation of cell migration
BPTASGO:0031581hemidesmosome assembly
BPIMPGO:0031589cell-substrate adhesion
BPIEAGO:0031668cellular response to extracellular stimulus
BPIEAGO:0033627cell adhesion mediated by integrin
BPIMPGO:0035878nail development
BPIMPGO:0042327positive regulation of phosphorylation
BPIGIGO:0043065positive regulation of apoptotic process
BPIMPGO:0043547positive regulation of GTPase activity
BPIMPGO:0043588skin development
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046847filopodium assembly
BPIMPGO:0048565digestive tract development
BPIEAGO:0050873brown fat cell differentiation
BPTASGO:0050900leukocyte migration
BPIEAGO:0071407cellular response to organic cyclic compound
BPIMPGO:0072001renal system development
BPIEAGO:0098609cell-cell adhesion
BPIMPGO:2001237negative regulation of extrinsic apoptotic signaling pathway
CCIEAGO:0005604basement membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0005913cell-cell adherens junction
CCHDAGO:0005925focal adhesion
CCIEAGO:0009897external side of plasma membrane
CCIEAGO:0009925basal plasma membrane
CCHDAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIEAGO:0034676integrin alpha6-beta4 complex

Gene expression in normal tissue: ITGA6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGA6

DatabasePathway IDPathway Des.
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-2022090Assembly of collagen fibrils and other multimeric structures
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210991Basigin interactions
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-3000157Laminin interactions
reactomeR-HSA-3000157Laminin interactions
reactomeR-HSA-3000170Syndecan interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-446107Type I hemidesmosome assembly
reactomeR-HSA-446728Cell junction organization
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidarf6_traffickingpathwayArf6 trafficking events
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin4_pathwayAlpha6 beta4 integrin-ligand interactions
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidplexind1_pathwayPlexin-D1 Signaling
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA6