ITGA6


Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:147556
PHARMGKB IDPA29942
Map Location2q31.1

GO terms in ITGA6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0005178 integrin binding
MF IPI GO:0005515 protein binding
MF IDA GO:0031994 insulin-like growth factor I binding
MF IDA GO:0038132 neuregulin binding
MF IEA GO:0043236 laminin binding
MF HDA GO:0045296 cadherin binding
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Gene expression in normal tissue: ITGA6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGA6


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1474290 Collagen formation
reactome R-HSA-1500931 Cell-Cell communication
reactome R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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