IRF1


Summary: The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017].

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Name
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Gene Categories:

TUMOR SUPPRESSOR

GO terms in IRF1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0002819 regulation of adaptive immune response
BP TAS GO:0006366 transcription by RNA polymerase II
BP IDA GO:0006915 apoptotic process
BP IDA GO:0007050 cell cycle arrest
BP TAS GO:0007596 blood coagulation
BP TAS GO:0008285 negative regulation of cell proliferation
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Gene expression in normal tissue: IRF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IRF1


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Database
Pathway ID
Pathway Des.
wikipathways WP2037 Prolactin Signaling Pathway
wikipathways WP254 Apoptosis
wikipathways WP2593 JAK-STAT
wikipathways WP3639 Apoptotic Signaling Pathway
wikipathways WP364 IL-6 signaling pathway
wikipathways WP4197 The human immune response to tuberculosis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD561 ABT-263 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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