IRF1
Summary: The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:147575 Ensembl IDEnsembl:ENSG00000125347 HGNC IDHGNC:HGNC:6116 PHARMGKB IDPA29915 Map Location5q31.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in IRF1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0002819 | regulation of adaptive immune response |
BP | TAS | GO:0006366 | transcription by RNA polymerase II |
BP | IDA | GO:0006915 | apoptotic process |
BP | IDA | GO:0007050 | cell cycle arrest |
BP | TAS | GO:0007596 | blood coagulation |
BP | TAS | GO:0008285 | negative regulation of cell proliferation |
Gene expression in normal tissue: IRF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRF1
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2037 | Prolactin Signaling Pathway |
wikipathways | WP254 | Apoptosis |
wikipathways | WP2593 | JAK-STAT |
wikipathways | WP3639 | Apoptotic Signaling Pathway |
wikipathways | WP364 | IL-6 signaling pathway |
wikipathways | WP4197 | The human immune response to tuberculosis |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD561 | ABT-263 | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in IRF1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |