IRF1
Summary: The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interferon regulatory factor 1 | MIM:147575 | Ensembl:ENSG00000125347 | HGNC:HGNC:6116 | PA29915 | 5q31.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in IRF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0002819 | regulation of adaptive immune response |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0032481 | positive regulation of type I interferon production |
| BP | IMP | GO:0032728 | positive regulation of interferon-beta production |
| BP | ISS | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway |
| BP | IDA | GO:0035458 | cellular response to interferon-beta |
| BP | IEA | GO:0043374 | CD8-positive, alpha-beta T cell differentiation |
| BP | IEA | GO:0045084 | positive regulation of interleukin-12 biosynthetic process |
| BP | TAS | GO:0045088 | regulation of innate immune response |
| BP | ISS | GO:0045590 | negative regulation of regulatory T cell differentiation |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | ISS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | ISS | GO:2000564 | regulation of CD8-positive, alpha-beta T cell proliferation |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IMP | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IMP | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: IRF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP4197 | The human immune response to tuberculosis |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | telomerasepathway | Regulation of Telomerase |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRF1
CLASSFICATION
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