Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015].

integrin subunit alpha 3MIM:605025Ensembl:ENSG00000005884HGNC:HGNC:6139PA2993917q21.33

GO terms in ITGA3

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001968fibronectin binding
MFIPIGO:0002020protease binding
MFIEAGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFIEAGO:0005518collagen binding
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0043236laminin binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0046982protein heterodimerization activity
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCTASGO:0008305integrin complex
CCIEAGO:0009897external side of plasma membrane
CCHDAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIEAGO:0016323basolateral plasma membrane
CCIEAGO:0030426growth cone
CCIDAGO:0031527filopodium membrane
CCIDAGO:0034667integrin alpha3-beta1 complex
CCIMPGO:0034667integrin alpha3-beta1 complex
CCIDAGO:0043235receptor complex
CCIEAGO:0048471perinuclear region of cytoplasm
CCIEAGO:0060076excitatory synapse
CCHDAGO:0070062extracellular exosome
CCIDAGO:0071438invadopodium membrane
CCIDAGO:0071944cell periphery
CCIEAGO:0097060synaptic membrane
BPIEAGO:0001764neuron migration
BPTASGO:0007160cell-matrix adhesion
BPIEAGO:0007229integrin-mediated signaling pathway
BPIEAGO:0007507heart development
BPIEAGO:0010628positive regulation of gene expression
BPIEAGO:0010634positive regulation of epithelial cell migration
BPIEAGO:0010811positive regulation of cell-substrate adhesion
BPIEAGO:0010976positive regulation of neuron projection development
BPIMPGO:0017015regulation of transforming growth factor beta receptor signaling pathway
BPIMPGO:0030111regulation of Wnt signaling pathway
BPTASGO:0030198extracellular matrix organization
BPIMPGO:0030324lung development
BPIMPGO:0030510regulation of BMP signaling pathway
BPIEAGO:0031345negative regulation of cell projection organization
BPIEAGO:0034698response to gonadotropin
BPIEAGO:0035024negative regulation of Rho protein signal transduction
BPIEAGO:0035640exploration behavior
BPIEAGO:0042493response to drug
BPIMPGO:0043588skin development
BPIEPGO:0048333mesodermal cell differentiation
BPTASGO:0050900leukocyte migration
BPIEAGO:0060135maternal process involved in female pregnancy
BPIMPGO:0072006nephron development
BPIEAGO:0097062dendritic spine maintenance
BPIMPGO:0097205renal filtration
BPIDAGO:1903078positive regulation of protein localization to plasma membrane

Gene expression in normal tissue: ITGA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGA3

DatabasePathway IDPathway Des.
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210991Basigin interactions
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-3000157Laminin interactions
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-8874081MET activates PTK2 signaling
reactomeR-HSA-8875878MET promotes cell motility
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
pidarf6_traffickingpathwayArf6 trafficking events
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pidil23pathwayIL23-mediated signaling events
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidplexind1_pathwayPlexin-D1 Signaling
pidreelinpathwayReelin signaling pathway
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA3