ITGA3
Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit alpha 3 | MIM:605025 | Ensembl:ENSG00000005884 | HGNC:HGNC:6139 | PA29939 | 17q21.33 |
GO terms in ITGA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001968 | fibronectin binding |
| MF | IPI | GO:0002020 | protease binding |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005518 | collagen binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0043236 | laminin binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | TAS | GO:0008305 | integrin complex |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0030426 | growth cone |
| CC | IDA | GO:0031527 | filopodium membrane |
| CC | IDA | GO:0034667 | integrin alpha3-beta1 complex |
| CC | IMP | GO:0034667 | integrin alpha3-beta1 complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0060076 | excitatory synapse |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071438 | invadopodium membrane |
| CC | IDA | GO:0071944 | cell periphery |
| CC | IEA | GO:0097060 | synaptic membrane |
| BP | IEA | GO:0001764 | neuron migration |
| BP | TAS | GO:0007160 | cell-matrix adhesion |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0007613 | memory |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IEA | GO:0010811 | positive regulation of cell-substrate adhesion |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | IMP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0030111 | regulation of Wnt signaling pathway |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IMP | GO:0030324 | lung development |
| BP | IMP | GO:0030510 | regulation of BMP signaling pathway |
| BP | IEA | GO:0031345 | negative regulation of cell projection organization |
| BP | IEA | GO:0034698 | response to gonadotropin |
| BP | IEA | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | IEA | GO:0035640 | exploration behavior |
| BP | IEA | GO:0042493 | response to drug |
| BP | IMP | GO:0043588 | skin development |
| BP | IEP | GO:0048333 | mesodermal cell differentiation |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0060135 | maternal process involved in female pregnancy |
| BP | IMP | GO:0072006 | nephron development |
| BP | IEA | GO:0097062 | dendritic spine maintenance |
| BP | IMP | GO:0097205 | renal filtration |
| BP | IDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
Gene expression in normal tissue: ITGA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-8874081 | MET activates PTK2 signaling |
| reactome | R-HSA-8875878 | MET promotes cell motility |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | il23pathway | IL23-mediated signaling events |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| pid | reelinpathway | Reelin signaling pathway |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGA3
CLASSFICATION
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