ITGA3


Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:605025
PHARMGKB IDPA29939
Map Location17q21.33

GO terms in ITGA3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001968 fibronectin binding
MF IPI GO:0002020 protease binding
MF IEA GO:0005178 integrin binding
MF IPI GO:0005515 protein binding
MF IEA GO:0005518 collagen binding
MF IEA GO:0019904 protein domain specific binding
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Gene expression in normal tissue: ITGA3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

VEGF signaling pathway1

Pathways in ITGA3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-202733 Cell surface interactions at the vascular wall
reactome R-HSA-210991 Basigin interactions
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD134 Sorafenib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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