ITGA9
Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603963 Ensembl IDEnsembl:ENSG00000144668 HGNC IDHGNC:HGNC:6145 PHARMGKB IDPA29945 Map Location3p22.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in ITGA9
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0008305 | integrin complex |
| CC | IEA | GO:0009925 | basal plasma membrane |
| CC | IEA | GO:0034679 | integrin alpha9-beta1 complex |
| BP | IGI | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
Gene expression in normal tissue: ITGA9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGA9
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGA9
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.