ITGA9
Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit alpha 9 | MIM:603963 | Ensembl:ENSG00000144668 | HGNC:HGNC:6145 | PA29945 | 3p22.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ITGA9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0008305 | integrin complex |
| CC | IEA | GO:0009925 | basal plasma membrane |
| CC | IEA | GO:0034679 | integrin alpha9-beta1 complex |
| BP | IGI | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0030593 | neutrophil chemotaxis |
| BP | IEA | GO:0042060 | wound healing |
| MF | IEA | GO:0005518 | collagen binding |
| MF | IEA | GO:0043236 | laminin binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ITGA9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGA9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | integrin_a9b1_pathway | Alpha9 beta1 integrin signaling events |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGA9
CLASSFICATION
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