ITGB3


Summary: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
integrin subunit beta 3MIM:173470Ensembl:ENSG00000259207HGNC:HGNC:6156PA20517q21.32

GO terms in ITGB3


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIBAGO:0005925focal adhesion
CCIDAGO:0005925focal adhesion
CCIBAGO:0008305integrin complex
CCIDAGO:0008305integrin complex
CCHDAGO:0009986cell surface
CCIBAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCTASGO:0031092platelet alpha granule membrane
CCIDAGO:0031258lamellipodium membrane
CCIDAGO:0031527filopodium membrane
CCIDAGO:0031528microvillus membrane
CCIDAGO:0032587ruffle membrane
CCIDAGO:0034683integrin alphav-beta3 complex
CCIDAGO:0035866alphav-beta3 integrin-PKCalpha complex
CCIDAGO:0035867alphav-beta3 integrin-IGF-1-IGF1R complex
CCIDAGO:0035868alphav-beta3 integrin-HMGB1 complex
CCIDAGO:0042470melanosome
CCIDAGO:0043235receptor complex
CCHDAGO:0070062extracellular exosome
CCTASGO:0071062alphav-beta3 integrin-vitronectin complex
BPTASGO:0001934positive regulation of protein phosphorylation
BPIMPGO:0001938positive regulation of endothelial cell proliferation
BPTASGO:0002576platelet degranulation
BPTASGO:0007155cell adhesion
BPIBAGO:0007160cell-matrix adhesion
BPIMPGO:0007160cell-matrix adhesion
BPHDAGO:0007229integrin-mediated signaling pathway
BPIBAGO:0007229integrin-mediated signaling pathway
BPTASGO:0007229integrin-mediated signaling pathway
BPTASGO:0007596blood coagulation
BPIMPGO:0010595positive regulation of endothelial cell migration
BPIMPGO:0010745negative regulation of macrophage derived foam cell differentiation
BPIMPGO:0010888negative regulation of lipid storage
BPIMPGO:0014909smooth muscle cell migration
BPIBAGO:0016477cell migration
BPIMPGO:0030168platelet activation
BPTASGO:0030198extracellular matrix organization
BPTASGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway
BPIMPGO:0031589cell-substrate adhesion
BPIMPGO:0032147activation of protein kinase activity
BPIMPGO:0032369negative regulation of lipid transport
BPIBAGO:0033627cell adhesion mediated by integrin
BPIDAGO:0033627cell adhesion mediated by integrin
BPIMPGO:0034113heterotypic cell-cell adhesion
BPIDAGO:0034446substrate adhesion-dependent cell spreading
BPTASGO:0035295tube development
BPIMPGO:0038027apolipoprotein A-I-mediated signaling pathway
BPICGO:0042060wound healing
BPIGIGO:0043277apoptotic cell clearance
BPTASGO:0045124regulation of bone resorption
BPIMPGO:0045715negative regulation of low-density lipoprotein particle receptor biosynthetic process
BPIMPGO:0046718viral entry into host cell
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEPGO:0048333mesodermal cell differentiation
BPIMPGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIMPGO:0050748negative regulation of lipoprotein metabolic process
BPTASGO:0050900leukocyte migration
BPIMPGO:0050919negative chemotaxis
BPTASGO:0060055angiogenesis involved in wound healing
BPIMPGO:0070527platelet aggregation
MFIEAGO:0001618virus receptor activity
MFIBAGO:0001968fibronectin binding
MFIMPGO:0001968fibronectin binding
MFIDAGO:0002020protease binding
MFIDAGO:0003756protein disulfide isomerase activity
MFTASGO:0005161platelet-derived growth factor receptor binding
MFIBAGO:0005178integrin binding
MFIPIGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFTASGO:0015026coreceptor activity
MFIDAGO:0017134fibroblast growth factor binding
MFIPIGO:0019899enzyme binding
MFIDAGO:0019960C-X3-C chemokine binding
MFIDAGO:0031994insulin-like growth factor I binding
MFIDAGO:0038132neuregulin binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0043184vascular endothelial growth factor receptor 2 binding
MFTASGO:0043184vascular endothelial growth factor receptor 2 binding
MFIPIGO:0050839cell adhesion molecule binding
MFIDAGO:0050840extracellular matrix binding
MFIBAGO:0070051fibrinogen binding

Gene expression in normal tissue: ITGB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGB3


DatabasePathway IDPathway Des.
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210990PECAM1 interactions
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-3000170Syndecan interactions
reactomeR-HSA-3000170Syndecan interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-354192Integrin alphaIIb beta3 signaling
reactomeR-HSA-354194GRB2:SOS provides linkage to MAPK signaling for Integrins
reactomeR-HSA-372708p130Cas linkage to MAPK signaling for integrins
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-445144Signal transduction by L1
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)
reactomeR-HSA-9006921Integrin signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartaedg1pathwayphospholipids as signalling intermediaries
pidarf6_pathwayArf6 signaling events
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidavb3_opn_pathwayOsteopontin-mediated events
pidil4_2pathwayIL4-mediated signaling events
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidnectin_pathwayNectin adhesion pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pharmgkbPA154444041Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
wikipathwaysWP12Osteoclast Signaling
wikipathwaysWP1434Osteopontin Signaling
wikipathwaysWP1455Serotonin Transporter Activity
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2806Human Complement System
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
wikipathwaysWP306Focal Adhesion
wikipathwaysWP322Osteoblast Signaling
wikipathwaysWP3301MFAP5-mediated ovarian cancer cell motility and invasiveness
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP727Monoamine Transport
smpdbSMP00265Abciximab Action Pathway
smpdbSMP00266Eptifibatide Action Pathway
smpdbSMP00267Tirofiban Action Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGB3

​​​​