KCNA6


Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008].

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GO terms in KCNA6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005249 voltage-gated potassium channel activity
MF TAS GO:0005249 voltage-gated potassium channel activity
MF IBA GO:0005251 delayed rectifier potassium channel activity
MF IDA GO:0005251 delayed rectifier potassium channel activity
BP TAS GO:0006813 potassium ion transport
BP IEA GO:0034765 regulation of ion transmembrane transport
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Gene expression in normal tissue: KCNA6

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in KCNA6


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Database
Pathway ID
Pathway Des.
humancyc PWY-7433 mucin core 1 and core 2 O-glycosylation
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296071 Potassium Channels
reactome R-HSA-1296072 Voltage gated Potassium channels
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNA6

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