KCNA6
Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily A member 6 | MIM:176257 | Ensembl:ENSG00000130035 | HGNC:HGNC:6225 | PA30022 | 12p13.32 |
GO terms in KCNA6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
| MF | TAS | GO:0005249 | voltage-gated potassium channel activity |
| MF | IBA | GO:0005251 | delayed rectifier potassium channel activity |
| MF | IDA | GO:0005251 | delayed rectifier potassium channel activity |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IDA | GO:0071805 | potassium ion transmembrane transport |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IMP | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0008076 | voltage-gated potassium channel complex |
| CC | ISS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0034705 | potassium channel complex |
| CC | IEA | GO:0043679 | axon terminus |
Gene expression in normal tissue: KCNA6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNA6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-7433 | mucin core 1 and core 2 O-glycosylation |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNA6
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