Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008].

potassium voltage-gated channel subfamily A member 6MIM:176257Ensembl:ENSG00000130035HGNC:HGNC:6225PA3002212p13.32

GO terms in KCNA6

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005249voltage-gated potassium channel activity
MFTASGO:0005249voltage-gated potassium channel activity
MFIBAGO:0005251delayed rectifier potassium channel activity
MFIDAGO:0005251delayed rectifier potassium channel activity
BPTASGO:0006813potassium ion transport
BPIEAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0051260protein homooligomerization
BPIBAGO:0071805potassium ion transmembrane transport
BPIDAGO:0071805potassium ion transmembrane transport
CCTASGO:0005886plasma membrane
CCIMPGO:0005887integral component of plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCIBAGO:0008076voltage-gated potassium channel complex
CCISSGO:0008076voltage-gated potassium channel complex
CCIBAGO:0016021integral component of membrane
CCISSGO:0034705potassium channel complex
CCIEAGO:0043679axon terminus

Gene expression in normal tissue: KCNA6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNA6

DatabasePathway IDPathway Des.
humancycPWY-7433mucin core 1 and core 2 O-glycosylation
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296072Voltage gated Potassium channels

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNA6