KCNB1
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600397 Ensembl IDEnsembl:ENSG00000158445 HGNC IDHGNC:HGNC:6231 PHARMGKB IDPA209 Map Location20q13.13 | |||||
GO terms in KCNB1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001508 | action potential |
| BP | ISS | GO:0006904 | vesicle docking involved in exocytosis |
| BP | ISS | GO:0007215 | glutamate receptor signaling pathway |
| BP | ISS | GO:0010701 | positive regulation of norepinephrine secretion |
| BP | ISS | GO:0031669 | cellular response to nutrient levels |
| BP | ISS | GO:0033605 | positive regulation of catecholamine secretion |
Gene expression in normal tissue: KCNB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNB1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNB1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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