Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008].

potassium voltage-gated channel subfamily B member 1MIM:600397Ensembl:ENSG00000158445HGNC:HGNC:6231PA20920q13.13

GO terms in KCNB1

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0001508action potential
BPISSGO:0006904vesicle docking involved in exocytosis
BPISSGO:0007215glutamate receptor signaling pathway
BPISSGO:0010701positive regulation of norepinephrine secretion
BPISSGO:0031669cellular response to nutrient levels
BPISSGO:0033605positive regulation of catecholamine secretion
BPIEAGO:0034765regulation of ion transmembrane transport
BPISSGO:0042593glucose homeostasis
BPISSGO:0045956positive regulation of calcium ion-dependent exocytosis
BPISSGO:0046676negative regulation of insulin secretion
BPTASGO:0050796regulation of insulin secretion
BPIEAGO:0051260protein homooligomerization
BPISSGO:0071333cellular response to glucose stimulus
BPIBAGO:0071805potassium ion transmembrane transport
BPIDAGO:0071805potassium ion transmembrane transport
BPISSGO:0071805potassium ion transmembrane transport
BPISSGO:0072659protein localization to plasma membrane
BPIDAGO:0090314positive regulation of protein targeting to membrane
BPISSGO:0090314positive regulation of protein targeting to membrane
BPISSGO:0098900regulation of action potential
BPISSGO:1900454positive regulation of long term synaptic depression
BPISSGO:2000671regulation of motor neuron apoptotic process
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0008076voltage-gated potassium channel complex
CCIDAGO:0008076voltage-gated potassium channel complex
CCISSGO:0008076voltage-gated potassium channel complex
CCIBAGO:0016021integral component of membrane
CCIEAGO:0016328lateral plasma membrane
CCIEAGO:0030054cell junction
CCIBAGO:0032590dendrite membrane
CCIBAGO:0032809neuronal cell body membrane
CCISSGO:0032809neuronal cell body membrane
CCIBAGO:0045211postsynaptic membrane
CCIEAGO:0045211postsynaptic membrane
MFIBAGO:0005249voltage-gated potassium channel activity
MFIBAGO:0005251delayed rectifier potassium channel activity
MFIDAGO:0005251delayed rectifier potassium channel activity
MFISSGO:0005251delayed rectifier potassium channel activity
MFIPIGO:0005515protein binding
MFIPIGO:0044325ion channel binding
MFISSGO:0046982protein heterodimerization activity

Gene expression in normal tissue: KCNB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNB1

DatabasePathway IDPathway Des.
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296072Voltage gated Potassium channels
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNB1