Summary: This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014].

potassium voltage-gated channel subfamily C member 1MIM:176258Ensembl:ENSG00000129159HGNC:HGNC:6233PA3002611p15.1

GO terms in KCNC1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005249voltage-gated potassium channel activity
MFTASGO:0005249voltage-gated potassium channel activity
MFIBAGO:0005251delayed rectifier potassium channel activity
MFISSGO:0005251delayed rectifier potassium channel activity
MFIEAGO:0019894kinesin binding
MFIEAGO:0044325ion channel binding
CCTASGO:0005886plasma membrane
CCIBAGO:0008076voltage-gated potassium channel complex
CCIDAGO:0008076voltage-gated potassium channel complex
CCISSGO:0008076voltage-gated potassium channel complex
CCIEAGO:0009986cell surface
CCIBAGO:0016021integral component of membrane
CCIBAGO:0032590dendrite membrane
CCIEAGO:0032590dendrite membrane
CCIBAGO:0032809neuronal cell body membrane
CCISSGO:0032809neuronal cell body membrane
CCIBAGO:0043025neuronal cell body
BPTASGO:0006813potassium ion transport
BPIEAGO:0009636response to toxic substance
BPIEAGO:0009642response to light intensity
BPIEAGO:0010996response to auditory stimulus
BPIEAGO:0014075response to amine
BPIEAGO:0021549cerebellum development
BPIEAGO:0021759globus pallidus development
BPIEAGO:0035690cellular response to drug
BPIEAGO:0035864response to potassium ion
BPIEAGO:0051260protein homooligomerization
BPIDAGO:0051262protein tetramerization
BPIEAGO:0071774response to fibroblast growth factor
BPIBAGO:0071805potassium ion transmembrane transport
BPISSGO:0071805potassium ion transmembrane transport
BPIEAGO:1903818positive regulation of voltage-gated potassium channel activity
BPIEAGO:1990089response to nerve growth factor

Gene expression in normal tissue: KCNC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNC1

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296072Voltage gated Potassium channels

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNC1