KCND1
Summary: This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300281 Ensembl IDEnsembl:ENSG00000102057 HGNC IDHGNC:HGNC:6237 PHARMGKB IDPA30029 Map LocationXp11.23 | |||||
GO terms in KCND1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
Gene expression in normal tissue: KCND1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCND1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCND1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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