Summary: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

potassium voltage-gated channel subfamily J member 4MIM:600504Ensembl:ENSG00000168135HGNC:HGNC:6265PA3004822q13.1

GO terms in KCNJ4

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005242inward rectifier potassium channel activity
MFTASGO:0005242inward rectifier potassium channel activity
MFIPIGO:0005515protein binding
MFTASGO:0015467G-protein activated inward rectifier potassium channel activity
MFIPIGO:0030165PDZ domain binding
CCTASGO:0005886plasma membrane
CCTASGO:0008076voltage-gated potassium channel complex
CCIDAGO:0016323basolateral plasma membrane
CCIEAGO:0030054cell junction
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIEAGO:0045211postsynaptic membrane
BPTASGO:0006813potassium ion transport
BPIBAGO:0010107potassium ion import
BPIBAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0034765regulation of ion transmembrane transport

Gene expression in normal tissue: KCNJ4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNJ4

DatabasePathway IDPathway Des.
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296041Activation of G protein gated Potassium channels
reactomeR-HSA-1296053Classical Kir channels
reactomeR-HSA-1296059G protein gated Potassium channels
reactomeR-HSA-1296065Inwardly rectifying K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576886Phase 4 - resting membrane potential
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-977443GABA receptor activation
reactomeR-HSA-977444GABA B receptor activation
reactomeR-HSA-991365Activation of GABAB receptors
reactomeR-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNJ4