KCNJ4
Summary: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600504 Ensembl IDEnsembl:ENSG00000168135 HGNC IDHGNC:HGNC:6265 PHARMGKB IDPA30048 Map Location22q13.1 | |||||
GO terms in KCNJ4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005242 | inward rectifier potassium channel activity |
| MF | TAS | GO:0005242 | inward rectifier potassium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015467 | G-protein activated inward rectifier potassium channel activity |
| MF | IPI | GO:0030165 | PDZ domain binding |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: KCNJ4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNJ4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| pharmgkb | PA2033 | Antiarrhythmic Pathway, Pharmacodynamics |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNJ4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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