KCNN1


Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
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GO terms in KCNN1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005516 calmodulin binding
MF TAS GO:0015269 calcium-activated potassium channel activity
MF IBA GO:0016286 small conductance calcium-activated potassium channel activity
MF IEA GO:0046982 protein heterodimerization activity
CC IBA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
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Gene expression in normal tissue: KCNN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in KCNN1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296052 Ca2+ activated K+ channels
reactome R-HSA-1296071 Potassium Channels
kegg hsa04911 Insulin secretion - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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