KCNN1
Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium calcium-activated channel subfamily N member 1 | MIM:602982 | Ensembl:ENSG00000105642 | HGNC:HGNC:6290 | PA30070 | 19p13.11 |
GO terms in KCNN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | TAS | GO:0015269 | calcium-activated potassium channel activity |
| MF | IBA | GO:0016286 | small conductance calcium-activated potassium channel activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043025 | neuronal cell body |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
Gene expression in normal tissue: KCNN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296052 | Ca2+ activated K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNN1
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