Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008].

potassium calcium-activated channel subfamily N member 1MIM:602982Ensembl:ENSG00000105642HGNC:HGNC:6290PA3007019p13.11

GO terms in KCNN1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005516calmodulin binding
MFTASGO:0015269calcium-activated potassium channel activity
MFIBAGO:0016286small conductance calcium-activated potassium channel activity
MFIEAGO:0046982protein heterodimerization activity
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0008076voltage-gated potassium channel complex
CCIBAGO:0043005neuron projection
CCIBAGO:0043025neuronal cell body
BPTASGO:0006813potassium ion transport
BPTASGO:0007268chemical synaptic transmission
BPIBAGO:0071805potassium ion transmembrane transport
BPIEAGO:0071805potassium ion transmembrane transport

Gene expression in normal tissue: KCNN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNN1

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296052Ca2+ activated K+ channels
reactomeR-HSA-1296071Potassium Channels
kegghsa04911Insulin secretion - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN1