Summary: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

potassium voltage-gated channel subfamily Q member 2MIM:602235Ensembl:ENSG00000075043HGNC:HGNC:6296PA3007420q13.33

GO terms in KCNQ2

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005249voltage-gated potassium channel activity
MFIDAGO:0005249voltage-gated potassium channel activity
MFIBAGO:0005251delayed rectifier potassium channel activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIDAGO:0005516calmodulin binding
MFIPIGO:0030506ankyrin binding
BPTASGO:0007268chemical synaptic transmission
BPTASGO:0007399nervous system development
BPIEAGO:0034765regulation of ion transmembrane transport
BPIBAGO:0071805potassium ion transmembrane transport
BPIDAGO:0071805potassium ion transmembrane transport
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0008076voltage-gated potassium channel complex
CCIDAGO:0008076voltage-gated potassium channel complex
CCIBAGO:0016021integral component of membrane
CCISSGO:0033268node of Ranvier
CCIBAGO:0043194axon initial segment
CCISSGO:0043194axon initial segment

Gene expression in normal tissue: KCNQ2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNQ2

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296072Voltage gated Potassium channels
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445095Interaction between L1 and Ankyrins
biocartaraccpathwayion channels and their functional role in vascular endothelium
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
kegghsa04725Cholinergic synapse - Homo sapiens (human)
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNQ2