KIF2A


Summary: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kinesin family member 2AMIM:602591Ensembl:ENSG00000068796HGNC:HGNC:6318PA1623933565q12.1

GO terms in KIF2A


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003774motor activity
MFIBAGO:0003777microtubule motor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008017microtubule binding
MFIDAGO:0008017microtubule binding
MFIBAGO:0016887ATPase activity
BPIGIGO:0000226microtubule cytoskeleton organization
BPTASGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIBAGO:0007018microtubule-based movement
BPTASGO:0007018microtubule-based movement
BPTASGO:0007019microtubule depolymerization
BPIDAGO:0007052mitotic spindle organization
BPIEAGO:0007399nervous system development
BPTASGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPIEAGO:0030154cell differentiation
BPIGIGO:0030334regulation of cell migration
BPIEAGO:0051301cell division
BPIMPGO:0090307mitotic spindle assembly
CCIDAGO:0000922spindle pole
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIBAGO:0005813centrosome
CCIDAGO:0005813centrosome
CCIDAGO:0005814centriole
CCIBAGO:0005819spindle
CCTASGO:0005829cytosol
CCIBAGO:0005871kinesin complex
CCIBAGO:0005874microtubule
CCIDAGO:0005874microtubule
CCIDAGO:0005876spindle microtubule
CCHDAGO:0016020membrane
CCIDAGO:0016604nuclear body
CCIEAGO:0097228sperm principal piece
CCIDAGO:0120103centriolar subdistal appendage

Gene expression in normal tissue: KIF2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KIF2A


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-141424Amplification of signal from the kinetochores
reactomeR-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-2132295MHC class II antigen presentation
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2500257Resolution of Sister Chromatid Cohesion
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663220RHO GTPases Activate Formins
reactomeR-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69618Mitotic Spindle Checkpoint
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-8856688Golgi-to-ER retrograde transport
reactomeR-HSA-983189Kinesins
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
pidplk1_pathwayPLK1 signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KIF2A

​​​​