KIF5A
Summary: This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kinesin family member 5A | MIM:602821 | Ensembl:ENSG00000155980 | HGNC:HGNC:6323 | PA30107 | 12q13.3 |
GO terms in KIF5A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005871 | kinesin complex |
| CC | TAS | GO:0005871 | kinesin complex |
| CC | IBA | GO:0005874 | microtubule |
| CC | IEA | GO:0005874 | microtubule |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0032839 | dendrite cytoplasm |
| CC | IEA | GO:0035253 | ciliary rootlet |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:1904115 | axon cytoplasm |
| BP | TAS | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | IBA | GO:0007018 | microtubule-based movement |
| BP | TAS | GO:0007018 | microtubule-based movement |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0007411 | axon guidance |
| BP | ISS | GO:0016192 | vesicle-mediated transport |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | IBA | GO:0030705 | cytoskeleton-dependent intracellular transport |
| BP | IBA | GO:0048489 | synaptic vesicle transport |
| BP | IBA | GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex |
| BP | IEA | GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex |
| BP | ISS | GO:1990049 | retrograde neuronal dense core vesicle transport |
| MF | TAS | GO:0003774 | motor activity |
| MF | IBA | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IBA | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed |
| MF | IBA | GO:0016887 | ATPase activity |
| MF | IEA | GO:0019894 | kinesin binding |
Gene expression in normal tissue: KIF5A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIF5A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-264876 | Insulin processing |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5625970 | RHO GTPases activate KTN1 |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-983189 | Kinesins |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KIF5A
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.