KIF5A


Summary: This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kinesin family member 5AMIM:602821Ensembl:ENSG00000155980HGNC:HGNC:6323PA3010712q13.3

GO terms in KIF5A


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005829cytosol
CCIBAGO:0005871kinesin complex
CCTASGO:0005871kinesin complex
CCIBAGO:0005874microtubule
CCIEAGO:0005874microtubule
CCHDAGO:0016020membrane
CCIEAGO:0032839dendrite cytoplasm
CCIEAGO:0035253ciliary rootlet
CCIEAGO:0043025neuronal cell body
CCIEAGO:0048471perinuclear region of cytoplasm
CCIEAGO:1904115axon cytoplasm
BPTASGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIBAGO:0007018microtubule-based movement
BPTASGO:0007018microtubule-based movement
BPTASGO:0007268chemical synaptic transmission
BPIBAGO:0007411axon guidance
BPISSGO:0016192vesicle-mediated transport
BPTASGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPIBAGO:0030705cytoskeleton-dependent intracellular transport
BPIBAGO:0048489synaptic vesicle transport
BPIBAGO:0098971anterograde dendritic transport of neurotransmitter receptor complex
BPIEAGO:0098971anterograde dendritic transport of neurotransmitter receptor complex
BPISSGO:1990049retrograde neuronal dense core vesicle transport
MFTASGO:0003774motor activity
MFIBAGO:0003777microtubule motor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008017microtubule binding
MFIEAGO:0008017microtubule binding
MFIBAGO:0008574ATP-dependent microtubule motor activity, plus-end-directed
MFIBAGO:0016887ATPase activity
MFIEAGO:0019894kinesin binding

Gene expression in normal tissue: KIF5A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KIF5A


DatabasePathway IDPathway Des.
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-2132295MHC class II antigen presentation
reactomeR-HSA-264876Insulin processing
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5625970RHO GTPases activate KTN1
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856688Golgi-to-ER retrograde transport
reactomeR-HSA-983189Kinesins
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KIF5A

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