TNPO1
Summary: This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transportin 1 | MIM:602901 | Ensembl:ENSG00000083312 | HGNC:HGNC:6401 | PA30192 | 5q13.2 |
Gene Categories:
TRANSPORTERGO terms in TNPO1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008139 | nuclear localization sequence binding |
| MF | TAS | GO:0008139 | nuclear localization sequence binding |
| MF | IEA | GO:0008536 | Ran GTPase binding |
| MF | IBA | GO:0008565 | protein transporter activity |
| CC | TAS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005929 | cilium |
| CC | IBA | GO:0031965 | nuclear membrane |
| CC | IBA | GO:0034399 | nuclear periphery |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0000060 | protein import into nucleus, translocation |
| BP | IBA | GO:0006607 | NLS-bearing protein import into nucleus |
| BP | IBA | GO:0006610 | ribosomal protein import into nucleus |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0035735 | intraciliary transport involved in cilium assembly |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
Gene expression in normal tissue: TNPO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNPO1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620924 | Intraflagellar transport |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNPO1
CLASSFICATION
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