KRT8


Summary: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:148060
PHARMGKB IDPA30234
Map Location12q13.13

Gene Categories:

DRUGGABLE GENOME

GO terms in KRT8


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0005198 structural molecule activity
MF IPI GO:0005515 protein binding
MF IEA GO:0044877 protein-containing complex binding
MF IPI GO:0097110 scaffold protein binding
CC HDA GO:0005634 nucleus
CC IEA GO:0005654 nucleoplasm
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Gene expression in normal tissue: KRT8

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in KRT8


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-6805567 Keratinization
reactome R-HSA-6809371 Formation of the cornified envelope
wikipathways WP2572 Primary Focal Segmental Glomerulosclerosis FSGS
netpath Pathway_EGFR1 EGFR1
pid p38alphabetadownstreampathway Signaling mediated by p38-alpha and p38-beta
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KRT8

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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