KRT13
Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| keratin 13 | MIM:148065 | Ensembl:ENSG00000171401 | HGNC:HGNC:6415 | PA30202 | 17q21.2 |
GO terms in KRT13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0007010 | cytoskeleton organization |
| BP | IEA | GO:0009314 | response to radiation |
| BP | TAS | GO:0031424 | keratinization |
| BP | IEA | GO:0043587 | tongue morphogenesis |
| BP | TAS | GO:0070268 | cornification |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| CC | HDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0045095 | keratin filament |
| CC | IDA | GO:0045111 | intermediate filament cytoskeleton |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IEA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: KRT13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KRT13
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-6805567 | Keratinization |
| reactome | R-HSA-6809371 | Formation of the cornified envelope |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KRT13
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.