RHOC
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:165380 Ensembl IDEnsembl:ENSG00000155366 HGNC IDHGNC:HGNC:669 PHARMGKB IDPA24951 Map Location1p13.2 | |||||
Gene Categories:
CELL SURFACEGO terms in RHOC
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000281 | mitotic cytokinesis |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | IBA | GO:0007163 | establishment or maintenance of cell polarity |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
Gene expression in normal tissue: RHOC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHOC
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHOC
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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