MAFA


Summary: MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MAF bZIP transcription factor AMIM:610303Ensembl:ENSG00000182759HGNC:HGNC:23145PA1349633618q24.3

GO terms in MAFA


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFTASGO:0042803protein homodimerization activity
MFNASGO:0046982protein heterodimerization activity
BPTASGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIDAGO:0007263nitric oxide mediated signal transduction
BPIDAGO:0009749response to glucose
BPIDAGO:0030073insulin secretion
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
CCIDAGO:0005634nucleus

Gene expression in normal tissue: MAFA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAFA


DatabasePathway IDPathway Des.
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04950Maturity onset diabetes of the young - Homo sapiens (human)
wikipathwaysWP1584Type II diabetes mellitus
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-210745Regulation of gene expression in beta cells

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAFA

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