STMN1
Summary: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| stathmin 1 | MIM:151442 | Ensembl:ENSG00000117632 | HGNC:HGNC:6510 | PA35491 | 1p36.11 |
GO terms in STMN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015631 | tubulin binding |
| MF | IDA | GO:0015631 | tubulin binding |
| MF | IMP | GO:0015631 | tubulin binding |
| BP | IMP | GO:0000281 | mitotic cytokinesis |
| BP | IBA | GO:0007019 | microtubule depolymerization |
| BP | IDA | GO:0007019 | microtubule depolymerization |
| BP | IMP | GO:0007019 | microtubule depolymerization |
| BP | IDA | GO:0007052 | mitotic spindle organization |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007409 | axonogenesis |
| BP | IEA | GO:0007420 | brain development |
| BP | IEP | GO:0009615 | response to virus |
| BP | IMP | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| BP | IMP | GO:0031115 | negative regulation of microtubule polymerization |
| BP | IBA | GO:0031175 | neuron projection development |
| BP | IMP | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| BP | IEA | GO:0051272 | positive regulation of cellular component movement |
| BP | IBA | GO:0051493 | regulation of cytoskeleton organization |
| BP | IMP | GO:0051497 | negative regulation of stress fiber assembly |
| BP | IMP | GO:0061436 | establishment of skin barrier |
| BP | IMP | GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway |
| BP | IMP | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity |
| CC | IDA | GO:0005622 | intracellular |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0005874 | microtubule |
| CC | IEA | GO:0016020 | membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: STMN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STMN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | aurora_b_pathway | Aurora B signaling |
| pid | p38gammadeltapathway | Signaling mediated by p38-gamma and p38-delta |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STMN1
CLASSFICATION
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