LCP2
Summary: This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601603 Ensembl IDEnsembl:ENSG00000043462 HGNC IDHGNC:HGNC:6529 PHARMGKB IDPA30313 Map Location5q35.1 | |||||
Gene Categories:
KINASEGO terms in LCP2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0036398 | TCR signalosome |
| CC | IDA | GO:0044853 | plasma membrane raft |
| BP | TAS | GO:0006955 | immune response |
Gene expression in normal tissue: LCP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LCP2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_TCR | TCR |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LCP2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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