ARHGAP6
Summary: This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300118 Ensembl IDEnsembl:ENSG00000047648 HGNC IDHGNC:HGNC:676 PHARMGKB IDPA24960 Map LocationXp22.2 | |||||
GO terms in ARHGAP6
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0007266 | Rho protein signal transduction |
| BP | IEA | GO:0009967 | positive regulation of signal transduction |
| BP | NAS | GO:0030041 | actin filament polymerization |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0048041 | focal adhesion assembly |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
Gene expression in normal tissue: ARHGAP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGAP6
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| biocarta | arappathway | adp-ribosylation factor |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGAP6
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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