ARHGAP6
Summary: This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Rho GTPase activating protein 6 | MIM:300118 | Ensembl:ENSG00000047648 | HGNC:HGNC:676 | PA24960 | Xp22.2 |
GO terms in ARHGAP6
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | NAS | GO:0007266 | Rho protein signal transduction |
BP | IEA | GO:0009967 | positive regulation of signal transduction |
BP | NAS | GO:0030041 | actin filament polymerization |
BP | IEA | GO:0043547 | positive regulation of GTPase activity |
BP | IEA | GO:0048041 | focal adhesion assembly |
BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
BP | IMP | GO:0051497 | negative regulation of stress fiber assembly |
BP | IMP | GO:0051895 | negative regulation of focal adhesion assembly |
CC | IMP | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | NAS | GO:0005884 | actin filament |
CC | ISS | GO:0015629 | actin cytoskeleton |
MF | TAS | GO:0005070 | SH3/SH2 adaptor activity |
MF | TAS | GO:0005096 | GTPase activator activity |
MF | IEA | GO:0017124 | SH3 domain binding |
Gene expression in normal tissue: ARHGAP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGAP6
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | rhoa_reg_pathway | Regulation of RhoA activity |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-194315 | Signaling by Rho GTPases |
reactome | R-HSA-194840 | Rho GTPase cycle |
biocarta | arappathway | adp-ribosylation factor |
biocarta | rac1pathway | rac1 cell motility signaling pathway |
biocarta | rhopathway | rho cell motility signaling pathway |
biocarta | tcrpathway | t cell receptor signaling pathway |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGAP6