LGALS3
Summary: This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| galectin 3 | MIM:153619 | Ensembl:ENSG00000131981 | HGNC:HGNC:6563 | PA30340 | 14q22.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in LGALS3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001772 | immunological synapse |
| CC | HDA | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005681 | spliceosomal complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
| BP | IDA | GO:0002548 | monocyte chemotaxis |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IEA | GO:0008380 | RNA splicing |
| BP | IDA | GO:0030593 | neutrophil chemotaxis |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | IMP | GO:0042129 | regulation of T cell proliferation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0045087 | innate immune response |
| BP | TAS | GO:0045637 | regulation of myeloid cell differentiation |
| BP | IDA | GO:0045806 | negative regulation of endocytosis |
| BP | IDA | GO:0048245 | eosinophil chemotaxis |
| BP | IDA | GO:0048246 | macrophage chemotaxis |
| BP | ISS | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| BP | IDA | GO:0050918 | positive chemotaxis |
| BP | IDA | GO:0070232 | regulation of T cell apoptotic process |
| BP | IDA | GO:0071674 | mononuclear cell migration |
| BP | IDA | GO:0071677 | positive regulation of mononuclear cell migration |
| BP | IDA | GO:0090280 | positive regulation of calcium ion import |
| BP | IMP | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | ISS | GO:2000521 | negative regulation of immunological synapse formation |
| BP | ISS | GO:2001189 | negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| BP | IDA | GO:2001200 | positive regulation of dendritic cell differentiation |
| BP | IDA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019863 | IgE binding |
| MF | IEA | GO:0030246 | carbohydrate binding |
| MF | IDA | GO:0042056 | chemoattractant activity |
| MF | IDA | GO:0043236 | laminin binding |
Gene expression in normal tissue: LGALS3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LGALS3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-879415 | Advanced glycosylation endproduct receptor signaling |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid cells |
| reactome | R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | ras_pathway | Regulation of Ras family activation |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP4105 | Transcriptional regulation by RUNX1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LGALS3
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