LIF
Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:159540 Ensembl IDEnsembl:ENSG00000128342 HGNC IDHGNC:HGNC:6596 PHARMGKB IDPA30370 Map Location22q12.2 |
GO terms in LIF
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005102 | signaling receptor binding |
MF | IBA | GO:0005125 | cytokine activity |
MF | IDA | GO:0005125 | cytokine activity |
MF | IBA | GO:0005146 | leukemia inhibitory factor receptor binding |
MF | IDA | GO:0005146 | leukemia inhibitory factor receptor binding |
MF | IPI | GO:0005146 | leukemia inhibitory factor receptor binding |
Gene expression in normal tissue: LIF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LIF
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Database | Pathway ID | Pathway Des. |
---|---|---|
pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
pid | p53downstreampathway | Direct p53 effectors |
kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in LIF
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |