LIF

Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameLIF, interleukin 6 family cytokine
OMIM IDMIM:159540
Ensembl IDEnsembl:ENSG00000128342
HGNC IDHGNC:HGNC:6596
PHARMGKB IDPA30370
Map Location22q12.2

GO terms in LIF


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005102 signaling receptor binding
MF IBA GO:0005125 cytokine activity
MF IDA GO:0005125 cytokine activity
MF IBA GO:0005146 leukemia inhibitory factor receptor binding
MF IDA GO:0005146 leukemia inhibitory factor receptor binding
MF IPI GO:0005146 leukemia inhibitory factor receptor binding
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Gene expression in normal tissue: LIF

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 20BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6

Gene-drug pathway distribution

undefined8ERK MAPK signaling1

Pathways in LIF


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Database
Pathway ID
Pathway Des.
pid fra_pathway Validated transcriptional targets of AP1 family members Fra1 and Fra2
pid p53downstreampathway Direct p53 effectors
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegg hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
kegg hsa04668 TNF signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD330 BRD4132 3
iGMDRD144 NSC95397 3
iGMDRD494 Neopeltolide 3
iGMDRD577 BIX01294 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LIF

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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