Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].

LIF, interleukin 6 family cytokineMIM:159540Ensembl:ENSG00000128342HGNC:HGNC:6596PA3037022q12.2

GO terms in LIF

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005102signaling receptor binding
MFIBAGO:0005125cytokine activity
MFIDAGO:0005125cytokine activity
MFIBAGO:0005146leukemia inhibitory factor receptor binding
MFIDAGO:0005146leukemia inhibitory factor receptor binding
MFIPIGO:0005146leukemia inhibitory factor receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIDAGO:0008083growth factor activity
BPIEAGO:0001974blood vessel remodeling
BPIEAGO:0006955immune response
BPIEAGO:0007260tyrosine phosphorylation of STAT protein
BPTASGO:0007275multicellular organism development
BPIEAGO:0007566embryo implantation
BPIBAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0008285negative regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0019827stem cell population maintenance
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIDAGO:0033141positive regulation of peptidyl-serine phosphorylation of STAT protein
BPIDAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIDAGO:0043410positive regulation of MAPK cascade
BPIBAGO:0045595regulation of cell differentiation
BPIDAGO:0045651positive regulation of macrophage differentiation
BPIEAGO:0045835negative regulation of meiotic nuclear division
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046888negative regulation of hormone secretion
BPIEAGO:0048286lung alveolus development
BPIEAGO:0048644muscle organ morphogenesis
BPIEAGO:0048666neuron development
BPIEAGO:0048711positive regulation of astrocyte differentiation
BPIBAGO:0048861leukemia inhibitory factor signaling pathway
BPIDAGO:0048861leukemia inhibitory factor signaling pathway
BPIEAGO:0048863stem cell differentiation
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0060426lung vasculature development
BPIEAGO:0060463lung lobe morphogenesis
BPIEAGO:0060707trophoblast giant cell differentiation
BPIEAGO:0060708spongiotrophoblast differentiation
BPIEAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIDAGO:0072108positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
BPIDAGO:0072307regulation of metanephric nephron tubule epithelial cell differentiation
BPIDAGO:1900182positive regulation of protein localization to nucleus
BPIDAGO:1901676positive regulation of histone H3-K27 acetylation
BPIEAGO:1903025regulation of RNA polymerase II regulatory region sequence-specific DNA binding
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCICGO:0005615extracellular space

Gene expression in normal tissue: LIF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LIF

DatabasePathway IDPathway Des.
pidfra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
pidp53downstreampathwayDirect p53 effectors
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP560TGF-beta Receptor Signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6783589Interleukin-6 family signaling
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-6788467IL-6-type cytokine receptor ligand interactions
biocartanfatpathwaynfat and hypertrophy of the heart

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LIF