LIF
Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIF, interleukin 6 family cytokine | MIM:159540 | Ensembl:ENSG00000128342 | HGNC:HGNC:6596 | PA30370 | 22q12.2 |
GO terms in LIF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005146 | leukemia inhibitory factor receptor binding |
| MF | IDA | GO:0005146 | leukemia inhibitory factor receptor binding |
| MF | IPI | GO:0005146 | leukemia inhibitory factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0008083 | growth factor activity |
| BP | IEA | GO:0001974 | blood vessel remodeling |
| BP | IEA | GO:0006955 | immune response |
| BP | IEA | GO:0007260 | tyrosine phosphorylation of STAT protein |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0019827 | stem cell population maintenance |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein |
| BP | IDA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IDA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IBA | GO:0045595 | regulation of cell differentiation |
| BP | IDA | GO:0045651 | positive regulation of macrophage differentiation |
| BP | IEA | GO:0045835 | negative regulation of meiotic nuclear division |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046697 | decidualization |
| BP | IDA | GO:0046888 | negative regulation of hormone secretion |
| BP | IEA | GO:0048286 | lung alveolus development |
| BP | IEA | GO:0048644 | muscle organ morphogenesis |
| BP | IEA | GO:0048666 | neuron development |
| BP | IEA | GO:0048711 | positive regulation of astrocyte differentiation |
| BP | IBA | GO:0048861 | leukemia inhibitory factor signaling pathway |
| BP | IDA | GO:0048861 | leukemia inhibitory factor signaling pathway |
| BP | IEA | GO:0048863 | stem cell differentiation |
| BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0060426 | lung vasculature development |
| BP | IEA | GO:0060463 | lung lobe morphogenesis |
| BP | IEA | GO:0060707 | trophoblast giant cell differentiation |
| BP | IEA | GO:0060708 | spongiotrophoblast differentiation |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0072108 | positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| BP | IDA | GO:0072307 | regulation of metanephric nephron tubule epithelial cell differentiation |
| BP | IDA | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IDA | GO:1901676 | positive regulation of histone H3-K27 acetylation |
| BP | IEA | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IC | GO:0005615 | extracellular space |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: LIF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LIF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | p53downstreampathway | Direct p53 effectors |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD268 | Cerulenin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LIF
CLASSFICATION
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