LIMK2
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIM domain kinase 2 | MIM:601988 | Ensembl:ENSG00000182541 | HGNC:HGNC:6614 | PA30387 | 22q12.2 |
GO terms in LIMK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005801 | cis-Golgi network |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | TAS | GO:0016310 | phosphorylation |
| BP | IEA | GO:0060322 | head development |
| BP | IEA | GO:0061303 | cornea development in camera-type eye |
Gene expression in normal tissue: LIMK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LIMK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cdc42_pathway | CDC42 signaling events |
| pid | rhoa_pathway | RhoA signaling pathway |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD247 | Blebbistatin | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD220 | fumonisin B1 | 1 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD246 | NPC26 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LIMK2
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